Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-04-26
2011-04-26
Fetterolf, Brandon J (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S235200, C514S275000, C544S332000, C544S331000, C544S122000, C435S184000
Reexamination Certificate
active
07932246
ABSTRACT:
Compounds of formula: (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: (I) wherein Q, V and W independently represent —N═ or —C═; B is a divalent radical selected from: (IIA), (IIB), (IIC), (IID), and (IIE). Wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; and -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical.
REFERENCES:
patent: WO 03/076401 (2003-09-01), None
patent: WO 03/076422 (2003-09-01), None
patent: WO 03/076430 (2003-09-01), None
Vippagunta, et al. Advanced Drug Delivery Reviews, 48, 2001, p. 18.
Belfield Andrew James
Mazzei Francesca Ann
Moffat David Festus Charles
Patel Sanjay Ratilal
Van Meurs Sandra
Banner & Witcoff , Ltd.
Chroma Therapeutics Ltd.
Cornet Jean
Fetterolf Brandon J
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