Histone deacetylase and methods of use thereof

Details Histone deacetylase and methods of use thereof Histone deacetylase and methods of use thereof

2002-06-17

2009-02-10

Fetterolf, Brandon J (Department: 1642)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C536S023100

Reexamination Certificate

active

07488587

ABSTRACT:
The present invention provides nucleic acid molecules that encode histone deacetylase, as well as recombinant vectors and host cells that include the subject nucleic acid molecules. Also provided are histone deacetylase polypeptide compositions. The histone deacteylase nucleic acid molecules are useful in a variety of diagnostic and therapeutic applications, which are also provided.

REFERENCES:
patent: 2003/0129724 (2003-07-01), Grozinger et al.
patent: WO 01/42437 (2001-06-01), None
patent: WO 03/006652 (2003-01-01), None
GenEmbl database for nucleotide sequences (Accession No. AF239243, Apr. 12, 2000).
GenEmbl database for nucleotide sequences (Accession No. AL117455, Feb. 18, 2000).
Kao et al. (Gene. Dev. 2000; 14: 55-66).
Database on Genbank, Li et al. “A novel class II HDAC is associated with the transcriptional homeodomain repressor CCAAT displacement protein,” Jun. 1, 2001, Accession No. Q9NYK9.
Database on Genbank, Shimkets et al. Human ORFX ORF2609 polynucleotide sequence SEQ ID No. 5217. Oct. 5, 2000, Accession No. AAC77054.
Database on Genbank, Li et al. “A novel class II HDAC is associated with the transcriptional homeodomain repressor CCAAT displacement protein,” Apr. 12, 2000, Accession No. AF239243.
Bertos et al. Class II histone deacetylase: Structure, function, and regulation.Biochem. Cell. Biol., May 14, 2001, vol. 79, No. 3 pp. 243-252.
Miska et al. (1999)EMBO J.18:5099-5107.
Lemercier et al. (2000)J. Biol. Chem.275:15594-15599.
Grozinger et al. (2000)Proc. Natl. Acad. Sci. USA97:7835-7840.
Huynh et al. (2000)Genes and Development14:1810-1823.
Huang et al. (2000)Genes Dev.14:45-54.
Kao et al. (2000)Genes Dev.14:55-66.
Kao et al., “Isolation of a novel histone deacetylase reveal that class I and class II deacetylases promote SMRT-mediated repression”, (2000), Genes & Development, vol. 14, pp. 55-66.
Fischle et al., (1999), “A New Family of Human Histone Deacetylases Related to Saccharomyces cerevisiae HDA1p” The Journal of Biological Chemistry, 274: 11713-11720.
Fischle et al., (2001) “Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3 in Vivo” The Journal of Biological Chemistry, 276: 35826-35835.
Fischle et al., (2001) “The Emerging Role of Class II Histone Deacetylases” Biochemistry and Cell Biology, 79: 337-348.
Weidle U.H. et al. “Inhibition of Histone Deacetylases: A New Strategy to Target Epigenetic Modifications for Anticancer Treatment” Anticancer Research, Helenic Anticancer Institute, Athens, GR. vol. 20, May 2000, pp. 1471-1485.
Sawa H. et al., “Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bc1-2-related protein Bad” Brain Tumor Pathology. 2001, vol. 18, No. 2, 2001, pp. 109-114.
Penn L.Z., “Apoptosis Modulators as Cancer Therapeutics” Current Opinion in Investigational Drugs, Current Drugs, London, GB, vol. 2, No. 5, May 2001, pp. 684-692.
Database Genbank, Aug. 28, 1998, “Homo sapiens 12q13.1 PAC RPCI5-1057120 (Rosewell Park Cancer Institute Human PAC Library) complete sequence” retrieved from NCBI, Database accession No. AC004466.

Affiliated with

Also associated with

Rating

Histone deacetylase and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histone deacetylase and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histone deacetylase and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4128640