Histone deacetylase 9

Details Histone deacetylase 9 Histone deacetylase 9

2007-11-06

2007-11-06

Woitach, Joseph (Department: 1633)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S041000, C435S071100

Reexamination Certificate

active

10491372

ABSTRACT:
The identification and cloning of histone deacetylase 9 (HDAC9) is disclosed, and in particular full length HCAC9 polypeptides and HDAC9 polypeptides which have deacetylase activity, and to nucleic acid molecules encoding these polypeptides. The uses of these polypeptides and nucleic acid molecules are disclosed, for example for screening for compounds that are capable of modulating HDAC9 biological activity.

REFERENCES:
patent: WO 01/42437 (2001-06-01), None
patent: WO 02/36783 (2002-05-01), None
patent: WO 02/50285 (2002-06-01), None
patent: WO 02/102323 (2002-12-01), None
patent: WO 02/102984 (2002-12-01), None
Manlknecht et al., Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9). Biochem Biophys Res Commun. Apr. 26, 2002;293(1):182-91.
Protein Sequence Searches—Feb. 2005 “us-10-491-372-1.rup” pp. 1-7.
Zhow et al., Cloning and characterization of a histone deacetylase, HDAC9. PNAS Sep. 11, 2001 vol. 98 No. 19 10572-10577.
Nagase et al., Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Wang et al., HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.Mol Cell Biol. Nov. 1999;19(11):7816-27.
Zhou, X., et al., “Cloning and characterization of a histone deacetylase, HDAC9”, pp. 10572-10577, P.N.A.S., vol. 98, Sep. 2001; and associated NCBI Accession No. AY032737.
N. R. Bertos, et al., “Class II histone deacetylases: Structure, function and regulation”, Biochem. Cell Biol., vol. 79: pp. 243-252, 2001.
Petrie, F.G., et al., “Role of a novel Class II histone deacetylase in normal and leukemia-associated transcriptional repression”, Blood, vol. 98, p. 568a, 2001, (abstract).
Wang, A.H., et al., “HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor”, Molecular and Cellular Biology, vol. 19, pp. 7816-7827, Nov. 1999.
Kao, H.-Y., et al., “Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression”, Genes & Development, vol. 14, pp. 55-66, Jan. 2000.
Yoshida, M., et al., “Potent and Specific Inhibition of Mammalian Histone Deacetylase Both in Vivo and in Vitro by Trichostatin A*”, J. of Biol. Chem., vol. 265, pp. 17174-17179, Oct. 1990.
Nagase, T., et al.,.“Prediction of the Coding Sequences of Unidentified Human Genes. XI. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro”, DNA Research, vol. 5, pp. 277-286, 1998.
U.S. Appl. No. 60/298,296, filed Jun. 14, 2001, Bristol-Myers Squibb Company.
Grozinger, Christina M. et al.,Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA, 96: 4868-73 (1990).
Petrie, Kevin et al.,The Histone Deacetylase 9 Gene Encodes Multiple Protein Isoforms, The Journal of Biological Chemistry, 278(18): 16059-16072 (2003).

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