Histone deacetylase-8 proteins, nucleic acids, and methods...

Details Histone deacetylase-8 proteins, nucleic acids, and methods... Histone deacetylase-8 proteins, nucleic acids, and methods...

2006-05-16

2006-05-16

Saidha, Tekchand (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C435S196000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07045126

ABSTRACT:
The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromatin structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.

REFERENCES:
patent: WO 00/10583 (2000-03-01), None
Joseph Buggy, et al.; “Cloning and Charaterization of Novel Human Histone Deacetylase, HDAC8.” Biochem. J., 2000, 350, pp. 199-205.

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