Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1991-07-12
1992-09-29
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530330, 546 16, 546209, 546210, 548147, 548200, 548336, A61K 3702, C07K 508
Patent
active
051514974
ABSTRACT:
Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof.
Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.
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Bauer et al., Chemical Abstracts, vol. 92 (1980) pp. 825-826 Abstract No. 42368f.
Kalbacher et al., Chemical Abstracts, vol. 84 (1976), p. 503 Abstract No. 3147w.
Anami Koretake
Furukawa Noboru
Hara Katsuyoshi
Hari Hiroaki
Haruta Jun-ichi
Japan Tobacco Inc.
Lee Lester L.
Yoshotomi Pharmaceutical Industries Ltd.
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