Histidine substituted growth hormone releasing factor analogs

Details Histidine substituted growth hormone releasing factor analogs Histidine substituted growth hormone releasing factor analogs

1995-06-05

1997-12-09

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 930DIG559, A61K 3825, C07K 1460

Patent

active

056960891

ABSTRACT:
Novel growth hormone releasing factor analogs are presented having the formula: ##STR1## wherein R.sub.1 is His, 3-MeHis, desNH.sub.2 His, Tyr, or desNH.sub.2 Tyr; R.sub.2 is Val, Leu, or Ile; R.sub.3 is Ala; R.sub.4 is Met, Leu, Ile, or Nle; R.sub.5 is Ser or Asn; R.sub.6 is an amino acid residue sequence selected from Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu or fragments thereof where the fragment is reduced in number by one to fifteen amino acid residues from the amino acid residue which carries the substituent X; and X is either OH or NH.sub.2, and the pharmaceutically acceptable acid or base addition salts thereof. The novel growth hormone releasing factor analogs demonstrate enhanced potency for the released growth hormone, have enhanced enzymatic stability, and can be administered to a subject having a deficiency of growth hormone or for improvement of growth performance in livestock.

REFERENCES:
patent: 4025499 (1977-05-01), Thomas
patent: 4517181 (1985-05-01), Ling et al.
patent: 4518586 (1985-05-01), Rivier et al.
patent: 4528190 (1985-07-01), Vale, Jr. et al.
patent: 4529595 (1985-07-01), Rivier et al.
patent: 4562175 (1985-12-01), Chang et al.
patent: 4563352 (1986-01-01), Rivier et al.
patent: 4585756 (1986-04-01), Brazeau, Jr. et al.
patent: 4595676 (1986-06-01), Spiess et al.
patent: 4605643 (1986-08-01), Bohlen et al.
patent: 4610976 (1986-09-01), Bohlen et al.
patent: 4617149 (1986-10-01), Di Marchi et al.
patent: 4618598 (1986-10-01), Conn
patent: 4622312 (1986-11-01), Felix et al.
patent: 4626523 (1986-12-01), Vale, Jr. et al.
patent: 4628043 (1986-12-01), Spiess et al.
patent: 4649039 (1987-03-01), Garlick et al.
patent: 4649131 (1987-03-01), Felix et al.
patent: 4689318 (1987-08-01), Kaiser et al.
patent: 4703035 (1987-10-01), Rivier et al.
patent: 4728726 (1988-03-01), Rivier et al.
patent: 4732972 (1988-03-01), Felix et al.
patent: 4734399 (1988-03-01), Felix et al.
patent: 4783524 (1988-11-01), Larsen et al.
patent: 4784987 (1988-11-01), Rivier et al.
patent: 4914189 (1990-04-01), Schally et al.
Frohman et al, The American Society for Clinical Investigation, Inc., vol. 83, pp. 1533-1540, (May 1989).
Rudinger, Peptide Hormones, pp. 1-7, (Jun. 1976).
Dayhoff, Margaret, Atlas of Protein Sequence and Structure, Washington: Nat. Biomed Res. Found. 1972, vol. 5, p. 96.
Schulz et al, Principles of Protein Structure. New York: Springer-Verlag. 1979, pp. 14-16.
Smith, J.A. and Rivier, J.E., Peptides: Chemistry and Biology, Proceedings of the American Peptide Symposium, Cambridge, Jun. 16-21, 1991.
Marshall, G.R., Peptides: Chemistry and Biology, Proceedings of the 10th American Symposium, St. Louis, May 23-28, 1987.
Derwent Abstract No. 88-111768/16 (1988).
Science, 218(5), 585 (1982).
Nature, 300, 276 (1982).
Proc. Natl. Acad. Sci. USA 79, 7909 (1982).
J. Clin. Endo. Metab. 57(3), 677 (1983).
Unlisted Drugs, 35(3), 41 (1983).
Nature, 303, 532 (1983).
Biochem. Biophys. Res. Comm., 119(1), 265 (1984).
Medical World, Mar. 12, 1984, p. 37.
Proc. 7th Inter. Cong. Endo, Quebec City, Jul. 1-7, 1984, paper N-873.
Proc. 7th Inter. Cong. Endo, Quebec City, Jul. 1-7, 1984, Abstracts N-885, N-887/889, N-891/893, N-849.
Biochem. Biophys. Res. Comm. 123(2), 497 (1984).
Biochem. Biophys. Res. Comm. 123(2), 854 (1984).
New York Times. Apr. 17, 1988, p. C1.
Molecular Endocrinology, 3(10), 1529 (1989).
Principles of Biochemistry, 5th Ed., pp. 1126-1129 (not dated).
Life Science, 46(7), 999 (1990).
Derwent Abstracts of WO 90/15821 (Dec. 27, 1990).
Frohman et al., The American Society for Clinical Investigation, Inc. vol. 83, pp. 1533-4015 (1989).
Rudiger Peptide Hormones, pp. 1-7 (1976).

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