Histidine stabilized immunoglobulin and method of preparation

Details Histidine stabilized immunoglobulin and method of preparation Histidine stabilized immunoglobulin and method of preparation

1985-01-09

1986-07-01

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424101, 530387, A61K 39395

Patent

active

045979669

ABSTRACT:
Histidine-stabilized immunoglobulin preparations and a method for their manufacture are disclosed. The present invention is particularly well suited for stabilization of human gamma globulin (IgG) preparations having a relatively low protein content. Preferred stabilized human gamma globulin preparations comprise about 5 wt-% or less gamma globulin, histidine at a concentration of about 0.025M to about 0.2M, and optionally glycine at a concentration of about 0.05M to about 0.5M. The pH value of the preparations is at least 6.0 but not more than 7.0. A pH value of about 6.4 is most preferred. Conductivity of the preparations is about 2 to about 4 millisiemens at 5.degree. C., preferably about 2.5 to about 3.5 millisiemens at 5.degree. C., and most preferably about 2.7 millisiemens at 5.degree. C.

REFERENCES:
patent: 4093606 (1978-06-01), Coval
patent: 4124576 (1978-11-01), Coval
patent: 4360457 (1982-11-01), Ono et al.
patent: 4362661 (1982-12-01), Ono et al.
patent: 4384993 (1983-05-01), Sato et al.
patent: 4434093 (1984-02-01), Zolton et al.
patent: 4439421 (1984-03-01), Hooper et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4477432 (1984-10-01), Hardie
Gerber, J. Immunol. 92, 885-888(1964).
Gerber, Arthritis Rheum. 17, 85-91(1974).

Affiliated with

Also associated with

Rating

Histidine stabilized immunoglobulin and method of preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histidine stabilized immunoglobulin and method of preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histidine stabilized immunoglobulin and method of preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1081912