Histidine-containing peptide nucleic acids

Details Histidine-containing peptide nucleic acids Histidine-containing peptide nucleic acids

1999-01-04

2000-08-22

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 221, 536 231, 536 2431, 536 253, C07H 2102, C07H 2104, C07H 1900, C12Q 168

Patent

active

061074705

ABSTRACT:
Peptide nucleic acids containing histidine moieties are provided. These compounds have applications including diagnostics, research and potential therapeutics.

REFERENCES:
Dueholm, K.L. et al., "Peptide Nucleic Acid (PNA) with a Chiral Backbone Based on Alanine", Biorg. Med. Chem. Letts., 1994, 4, 1077-1080.
Egholm, P.E. et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science, 1991, 254, 1497-1500.
Egholm, M. et al., "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone", J. Am. Chem Soc., 1992, 114, 1895-1897.
Egholm, M. et al., "Recognition of Guanine and Adenine inDNA by Cytosine and Thymine Containing Peptide Nucleic Acids (PNA)", J. Am. Chem Soc., 1992, 114, 9677-9678.
Egholm, M. et al., "Peptide Nucleic Acids containing Adenine or Guanine recognise Thymine and Cytosine in Complementary DNA Sequences", J. Chem. Soc. Chem. Comm., 1993, 800-801.
Egholm, M. et al., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen bonding rules", Nature, 1993, 365, 566-568.
Greene and Wuts, Protective Groups in Organic Synthesis, 2d Edition, John Wiley & Sons, New York, 1991.
Hanvey, J.C. et al., "Antisense and Antigene Properties of Peptide Nucleic Acids", Science, 1992, 258, 1481-1485.
Helene, C. et al., "Specific regulation of gene expression by antisense, sense, and antigene nucleic acids", Biochimica et Biophysica Acta, 1990, 1049, 99-125.
Hyrup, B. et al., "Modification of the Biniding Affinity of Peptide Nucleic Acids (PNA). PNA with extended Backbones Consisting of 2-Aminoethyl-.beta.-alanine or 3-Aminopropylglycine Units", J. Chem. Soc. Chem. Commun., 1993, 518-519.
Lagriffoul, P.H. et al., "The Synthesis, Co-Oligomerization and Hybridization of a Thymine-Thymine Heterodimer Containing PNA", Bioor. Med. & Chem. Letts., 1994, 4, 1081-1082.
Nielsen, P.E. et al., "Sequence-Selective Recognition of DNA restriction enzyme cleavage by PNA", Nucl. Acids Res., 1993, 21, 197-200.
Orum, H. et al., "Single base pair mutation analysis by PNA directed PCR clamping", Nucl. Acids Res., 1993, 21(23), 5332-5336.
Uhlmann, E. et al., "Antisense Oligonucleotides: A New Therapeutic Principle", Chem. Reviews, 1990, 90, 544-584.

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