Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-27
1998-04-21
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483391, 514400, A61K 31415
Patent
active
057418071
ABSTRACT:
A method of preventing or reducing fluid and electrolyte losses in mammalian subjects under the effect of a stimulus that directly or indirectly causes such losses, by administering a therapeutically effective amount of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and pharmaceutically acceptable salts in conjunction with a carrier. In one embodiment the method is useful in reducing or preventing intestinal tract fluid secretions, and fluid and electrolyte losses associated with diarrhea arising from a number of causative agents, such as infectious diarrheas and non-infectious diarrheas. Various therapeutic regimes of histidine administration and formulation are embodied. Therapeutic compositions of histidine in combination with other medicaments, e.g., those that produce a diarrheal side-effect, are disclosed as another embodiment.
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Angres Iassc A.
Cytos Pharmaceuticals, L.P.
Higel Floyd D.
Petraglia Susan P.
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