Histamine H3 receptor antagonists, preparation and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S252130, C514S254010, C514S319000, C514S422000, C544S141000, C544S372000, C546S205000, C548S518000

Reexamination Certificate

active

07902191

ABSTRACT:
The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.

REFERENCES:
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patent: WO 02/076925 (2002-10-01), None
patent: WO 03/064411 (2003-08-01), None
Ferrari, et al., New Series of b-adrenergic blocking agents, Bollettino Chimico Farmaceutico 103(1), 32-6 (1964).
Fujimura, et al., Syntheses and Pharmacological Action of Tetralin Derivatives, Yakugaku Zasshi, 74, 954-6 (1954).
Hancock, et al., Antiobesity Effects of A-331440, a Novel Non-imidazole Histamine H Receptor Antagonist, European J. of Pharm., 487, 183-197 (2004).
Fujimura et al., “Syntheses and pharmacological action of Tetralin derivates,”Yakugaku Zasshi—Journal of the Pharmaceutical Society of Japan, No. 74, pp. 954-956, 1954.

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