Histamine H3 receptor agents, preparation and therapeutic uses

Details Histamine H3 receptor agents, preparation and therapeutic uses Histamine H3 receptor agents, preparation and therapeutic uses

2005-03-25

2009-12-15

Hui, Sam-ming (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S518000

Reexamination Certificate

active

07632857

ABSTRACT:
The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.

REFERENCES:
patent: WO 02/076295 (2002-10-01), None
patent: WO 03/064411 (2003-08-01), None
patent: WO 2004/076412 (2004-09-01), None
patent: WO 2005/082893 (2005-09-01), None
de Ferranti S, and Mozaffarian D, “The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences,” Clinical Chemistry, Jun. 2008, 54(6), 945-955.
Dick JJ, “Weight loss interventions for adult obesity: evidence for practice,” Worldviews on Evidence-Based Nursing, 2004, 1(4), 209-214.
Esbenshade TA, Fox GB, and Cowart MD, “Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders,” Molecular Interventions, Apr. 2006, 6(2), 77-88.
Hancock AA, Bush EN, Jacobson PB, Faghih R, and Esbenshade TA, “Histamine H(3) antagonists in models of obesity,” Inflammation Research, Mar. 2004, 53(Suppl 1), S47-S48.

Affiliated with

Also associated with

Rating

Histamine H3 receptor agents, preparation and therapeutic uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histamine H3 receptor agents, preparation and therapeutic uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histamine H3 receptor agents, preparation and therapeutic uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4149191