Histamine H2 receptor and uses

Details Histamine H2 receptor and uses Histamine H2 receptor and uses

2005-10-11

2005-10-11

Murphy, Joseph (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S006120, C530S350000, C536S023100

Reexamination Certificate

active

06953673

ABSTRACT:
The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.

REFERENCES:
patent: 5994506 (1999-11-01), Soppet et al.
Voet et al. Biochemistry. 1990. John Wiley & Sons, Inc. pp. 126-128 and 228-234.
Mickle JE et al. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. 2000 May;84(3):597-607.
Eck & Wilson in Goodman & Gilman's The Pharmacological Basis of Therapeutics. Ninth Edition. McGraw-Hill, New York, 1996, pp. 77-101.

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