Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-10-29
1996-01-23
Geist, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546203, 546210, 5483147, 514326, 514397, C07D41100, C07D21106, C07D23300, A01N 4340
Patent
active
054865263
ABSTRACT:
The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H.sub.3 -receptor antagonists. Such compounds have affinity for histamine H.sub.3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H.sub.3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.
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Durant Graham J.
Khan Amin M.
Tedford Clark E.
Geist Gary L.
Gliatech Inc.
Harris C.
The University of Toledo
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