Histamine H.sub.1 -receptor antagonists

Details Histamine H.sub.1 -receptor antagonists Histamine H.sub.1 -receptor antagonists

1987-02-27

1988-08-23

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544408, 544295, 544316, 544335, 544336, C07D40304, C07D40112, A61K 31495

Patent

active

047662158

ABSTRACT:
The compounds of the following formula are histamine H.sub.1 -receptor antagonists: ##STR1## where R.sup.3 and R.sup.4 are, independently, hydrogen, halo, alkoxy of 1 to 3 carbon atoms or alkyl of 1 to 3 carbon atoms; R.sup.2 is hydrogen or halo;

REFERENCES:
patent: 2979508 (1961-04-01), Janssen
patent: 2985657 (1961-05-01), Janssen
patent: 4550116 (1985-10-01), Soto et al.
patent: 4605655 (1986-08-01), Yevich et al.
Patel, Chem. Abstracts, vol. 75, (1971), entry 31808x.
Sonurlikar et al., Chem. Abstracts, vol. 89, (1978), entry 141166u.
Vadadaria et al., Chem. Abstracts, vol. 71, (1969), entry 101817t.
Merck Index, 9th ed., (1976), p. 170, entry #912.

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