Histamine derivatives as immune modulators

Details Histamine derivatives as immune modulators Histamine derivatives as immune modulators

1987-01-13

1991-02-26

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548342, 548344, 514 19, 514398, 530807, A61K 31415, C07D23364

Patent

active

049962213

ABSTRACT:
Histamine derivatives are disclosed which find use as effect and tissue-specific immune modulators. Specifically, the primary terminal nitrogen in histamine is derivatized to introduce a variable length side chain having 0 to 1 branch of from 1 to 3 carbons; 0 to 2 non-oxo-carbonyl groups; 0 to 4 heteroatoms, other than the non-oxo carbonyl oxygen; 0 to 1 aryl or alkyl-aryl group; and 0 to 1 functionally bound amino acid, polypeptide, or protein or derivative thereof.

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patent: 4532331 (1985-07-01), Frazee et al.
patent: 4687873 (1987-08-01), Goodman et al.
patent: 4837305 (1987-01-01), Goodman et al.
Khan, Journal of Immunology, vol. 137, No. 1, 1986, pp. 308-314.
Khan et al, The Journal of Immunology, vol. 134, No. 6, (6/1985), pp. 4100-4106.
Piptide Hormones, 6/1976, Rudinger et al, pp. 1-7.

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