Hirudin variants

Details Hirudin variants Hirudin variants

1989-03-08

1992-02-11

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530855, 435 692, 435 696, C07K 710, A61K 3764

Patent

active

050876139

ABSTRACT:
The present invention relates to hirudin variants having a modified peptide structure, relative to a parent hirudin variant. The new hirudin variants of the present invention display improve biological properties relative to the parent variant.

REFERENCES:
Winter, G. "Rodesigning enzyme structure by site-directed mutagenesis . . . " Nature 299, 756-758 (10/21/82).
White A., in "Principles of Biochemistry," Sixth Ed. pp. 860-863 (1978).
Dodt, J. "Interaction of site specific hirudin variants w/ .alpha.Thrombin".
Clare et al. Embo J. vol. 6, pp. 529-537 1987.

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