Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1995-06-07
1998-01-06
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 692, 514 12, 530324, 530412, C12Q 156, C12P 2102, A61K 3858, C07K 14815
Patent
active
057053553
ABSTRACT:
The present invention relates to vectors for cloning, in a host cell, hirudin or an analog of hirudin, characterized in that it comprises the gene for encoding hirudin or an analog of hirudin, and the elements for the expression of this gene in said host cell, said coding gene beginning, after the starting sequence, by an Ile codon and a Thr codon. This invention also relates to the process for the preparation of hirudin or analogs of hirudin as well as the hirudin or anologs of hirudin obtained.
REFERENCES:
patent: 4654302 (1987-03-01), Fritz et al.
patent: 5422249 (1995-06-01), Liersch et al.
Baskova, I.P. et al. (1983) "Hirudin from leech heads and whole leeches and `pseudo-hirudin` from leech bodies" Thromb. Res. 30(5):459-467.
Courtney Michael
Harvey Richard
LeCocq Jean-Pierre
Tolstoshev Paul
Lau Kawai
Transgene S.A.
Wax Robert A.
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