Hirudin HV2 having a SN7LYS substitution, method of making, and

Details Hirudin HV2 having a SN7LYS substitution, method of making, and Hirudin HV2 having a SN7LYS substitution, method of making, and

1995-06-07

1997-07-22

Jagannathan, Vasu S.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 691, 4353201, 435243, 514 2, 530300, C12P 2106, C12N 1500, C07K 14815

Patent

active

056503016

ABSTRACT:
The present invention relates to variants of hirudin containing an amino acid different from the amino acid in the natural form at position 47 or 63.

REFERENCES:
Rydel et al., Science, 1990, vol. 249, pp. 277-280.
Thrombin Inhibition by Hirudin Fragments: Possible Mechanism of Hirudin-Thrombin Interaction; S. Bajusz, I. Fauszt, E. Barabas, M. Dioszegi, et al.
Itakura et al. Science vol. 209 pp. 1401-1405 (1980).
Harvey, R.P. et al., "Cloning and expression of a DNA coding for the antiocoagulant hirudin from the bloodsucking leech, Hirudo medicinalis" From Report --Proceedings fo the National Academy of Sciences of the USA 83 (1986), pp. 1084-1088.
Harvey, R.P. et al., "Cloning and expresion of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis" From Report --Proceedings of the National Academy of Sciences of the USA 83 (1986), pp. 1084-1088.
Dodt et al FEBS vol. 165 pp. 180-184 (1984).
Itakira et al Science vol. 209 pp. 1401-1405 (1980).

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