Hirudin-coated biocompatible substance

Details Hirudin-coated biocompatible substance Hirudin-coated biocompatible substance

1988-08-03

1992-12-01

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424424, 424425, 424426, 424422, 523112, 523113, 6048901, 604113, 530300, A61F 200, A61K 922

Patent

active

051679604

ABSTRACT:
Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorpeoreal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or fragment thereof.

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