Hippocampus-associated proteins; DNA sequences coding therefor a

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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435 691, 536 231, 536 243, 536 232, C12N 902, C12P 2106, C07H 1700

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059768509

ABSTRACT:
This invention provides novel hippocampus-associated proteins and DNA sequences coding therefor. In an investigation of hippocampus-associated proteins by differential screening of a rat hippocampus cDNA library, a cDNA species encoding a novel protein designated Hct-1 was isolated and shown to be a to cytochromes P450. The use of hybridization probes based on the rat Hct-1 sequence has led to the identification of homologues in other mammalian species.

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Bahmre et al. "Microsomal cytochrome P450 . . . " Biochem. Pharmacology, vol. 44 No. 6, Sep. 25, 1992, pp. 1223-1225.
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Volk. "Mapping of phenytoin-inducible cytochrome p450 . . . " Neuroscience, vol. 42 No. 1, 1991, pp. 215-235.
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