Highly sensitive bead-based multi-analyte assay system using opt

Details Highly sensitive bead-based multi-analyte assay system using opt Highly sensitive bead-based multi-analyte assay system using opt

1998-07-21

2000-12-12

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

435 71, 435 793, 435 794, 435174, 436172, 436174, 436518, 436527, 436524, 436528, 436529, 436533, 436534, 436543, 436544, 436545, 436546, 250251, 2504581, 2504591, 356346, G01N 33552, G01N 33543, G01N 3353, F21V 916, G01R 902

Patent

active

06159749&

ABSTRACT:
An apparatus and method for chemical and biological analysis, the apparatus having an optical trapping means to manipulate the reaction substrate, and a measurement means. The optical trapping means is essentially a laser source capable of emitting a beam of suitable wavelength (e.g., Nd:YAG laser). The beam impinges upon a dielectric microparticle (e.g., a 5 micron polystyrene bead which serves as a reaction substrate), and the bead is thus confined at the focus of the laser beam by a radial component of the gradient force. Once "trapped," the bead can be moved, either by moving the beam focus, or by moving the reaction chamber. In this manner, the bead can be transferred among separate reaction wells connected by microchannels to permit reactions with the reagent affixed to the bead, and the reagents contained in the individual wells.

REFERENCES:
patent: 4893886 (1990-01-01), Ashkin et al.
patent: 5512745 (1996-04-01), Finer et al.
patent: 5620857 (1997-04-01), Weetall et al.
patent: 5736410 (1995-06-01), Zarling et al.
Schutze et al., Catch and Move, Nature 368: 667-669 (Apr. 14, 1994).
Buican et al., Automated single cell manipulation and sorting by light trapping, Applied Optics 26(24): 5311-5316 (Aug. 1, 1987).

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