Highly selective process for making o-arylbenzonitriles

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C07C25500

Patent

active

061538108

ABSTRACT:
Disclosed is a method of making an o-arylbenzonitrile by reacting o-chlorobenzonitrile with a substituted phenylzinc halide. The reaction is performed in the presence of a nickel catalyst, an ethereal solvent, and N-methylpyrrolidinone as a cosolvent.

REFERENCES:
patent: 5240928 (1993-08-01), Allen et al.
Danishefsky, S., et al, Selective Carbon-Carbon Bond Formation via Transition Metal Catalysis, 3. A Highly Selective Synthesis of Unsymetrical Biaryls and diarylmethanes by the Nickel-or Palladium-Catalyzed Reaction of Aryl-and Benzylzinc Derivatives, 1977.

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