Highly selective inhibitors of the urokinase plasminogen...

Details Highly selective inhibitors of the urokinase plasminogen... Highly selective inhibitors of the urokinase plasminogen...

2005-01-11

2005-01-11

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S157000, C564S239000

Reexamination Certificate

active

06841702

ABSTRACT:
The invention relates to novel selective inhibitors of the urokinase plasminogen activator (uPA, EC 3.4.21.31), of the arylguanidine type.

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S. Sperl et al., “(4-Aminomethyl)phenylguanidine Derivatives As Nonpeptidic Highly Selective Inhibitors of Human Urokinase,” Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, US. vol. 97, No. 10. May 9, 2000, pp. 5113-5118, OPoo2169711.
R. Rai et al., “Guanidinophenyl-Substituted Enol Lactones As Selective Mechanism-Based Inhibitors of Trypsin-Like Serine Proteases,” Journal of Medicinal Chemistry, American Chemical Society, Washington, US. vol. 35, No. 22, 1992, pp. 4160-4159, XP000978771.
Y. Heechung et al., “Selective Inhibition of Urokinase By Substituted Phenylguanidines: Quantitative Structure-Activity Relationship Analyses,” Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 33, No. 11, 1990, pp. 2956-2961, XP002059264.

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