Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-09-09
1995-11-07
Wax, Robert
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 691, 435 695, 435 6952, 43525233, 4353201, 530412, 530414, 530416, 530417, 530418, 536 221, 536 231, 536 232, 536 235, C07K 300, C12P 2106, C12N 120, C07H 1900
Patent
active
054649390
ABSTRACT:
A substantially pure non-glycosylated human interleukin-2 protein having a specific activity of not less than 10.sup.4 U/mg is obtained by growing a transformant carrying a DNA having a base sequence coding for human interleukin-2 to cause production and accumulation of human interleukin-2 in the culture broth, subjecting the thus obtained human interleukin-2-containing liquid to a purification process comprising a hydrophobic column chromatography.
REFERENCES:
patent: 4490289 (1984-12-01), Stern
patent: 4518584 (1985-05-01), Mark et al.
patent: 4530787 (1985-07-01), Shaked et al.
patent: 4564593 (1986-01-01), Tsukamoto et al.
patent: 4569790 (1986-02-01), Koths et al.
Riendeau, D., et al., Journal of Biological Chemistry 258(20):12114-12117 (1983).
1062 TMOG 137, Jan. 7, 1986.
Fred E. Regnier et al., "High-Performance Liquid Chromatography of Proteins", Analytical Biochemistry 103, 1-25 (1980).
Hans Neurath et al., "The Proteins", p. 198, 1975.
James W. Mier et al., "Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media", Proc. Natl. Acad. Sci. USA vol. 77, No. 10 pp. 6134-6138, Oct. 1980.
Harald S. Conradt et al., "Structures of the major carbohydrates of natural human interleukin-2", Eur. J. Biochem. 153, 255-261 (1985).
Steven Gillis et al., "Biochemical Characterization of Lymphocyte Regulatory Molecules", The Journal of Immunology vol. 124, No. 4, Apr. 1980.
Programme and Abstracts, 3rd International Symposium on HPLC of Proteins, Peptides and Polynucleotides, Nov. 14-16, 1983.
Louis E. Henderson et al. "A Rapid, Large Scale Purification For Gibbon Interleukin 2.sup.1 ", The Journal of Immunology, vol. 131, No. 2, Aug., 1983.
J. Immun. 133 (2) 1078 (Aug. 1984).
"Biological Response Modifiers Program (Ad)", J. Immun. 133 (Aug. 1984).
Biochem & Biophysical Res. Comm. 135 (3):837-843 (1986).
Biochem & Biophysical Res. Comm. 130 (2):692-699 (1985).
Biochem. & Biophysical Res. Comm. 128 (1):257-264 (1985).
Biochem. & Biophysical Res. Comm. 127 (1):182-190 (1985).
Science, 193, 1007-1008 (1976).
Immunological Reviews, 51, 257-278 (1980).
The Journal of Immunology, 123, 2928-2929 (1979).
Nature, 268, 154-156 (1977).
The Journal of Immunology, 130, 981-987 (1983).
The Journal of Immunology, 125, 1904-1909 (1980).
The Journal of Immunology, 130, 1784-1789 (1983).
The Journal of Immunology, 130, 1970-1973 (1983).
European Journal of Immunology, 10, 719-722 (1980).
Nature, 284, 278-280 (1980).
Nature, 302, 305-310 (1983).
Nucleic Acids Research, 11, 4307-4323 (1983).
Biochemical and Biophysical Research Communication, 109, 363-369 (1982).
Cell, 8, 163-182 (1976).
Nucleic Acids Research 9, 2251-2266 (1981).
Methods in Enzymology, 68, 41-50 (1979).
Proc. Natl. Acad. Sci. USA, 72, 3961-3965 (1975).
Method in Enzymology, 68, 220-242 (1979).
Proc. Natl. Acad. Sci. USA, 74, 560-564 (1977).
Nucleic Acids Research, 9, 309-321 (1981).
Proc. Natl. Acad. Sci. USA, 73, 4174-4178 (1976).
Nature, 217, 1110-1114 (1968).
Cell, 25, 713-719 (1981).
Proc. Natl. Acad. Sci. USA, 69, 2110-2114 (1972).
J. Experiments in Molecular Genetics, pp. 431-433 (Cold spring Harbor Laboratory, New York, 1972).
Journal of Immunology, 130, 988-992 (1983).
The Journal of Immunology, 120, 2027-2032 (1978).
Haemostasis, 7, 183-188 (1978).
J. Molecular Biology, 96, 495-509 (1975).
Proc. Natl. Acad. Sci. USA, 75, 5765-5769 (1978).
Nucleic Acids Research, 9, 6103-6114 (1981).
Nucleic Acids Research, 7, 1513-1523 (1979).
Methods in Enzymology, 11, 197-199 (1967).
Analytical Biochem., 67, 438-445 (1975).
Nucleic Acids Research, 11, 3077-3085 (1983).
Nucleic Acids Research, 11, 4307-4323 (1983).
J. Exp. Med., 156, 454-464 (1982).
Proc. Natl. Acad. Sci. USA, 80, 5990-5994 (1983).
Haruo Onda
Koichi Kato
Takao Yamada
Conlin David G.
Eisenstein Ronald I.
Kim Hyosuk
Takeda Chemical Industries Ltd.
Wax Robert
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