Highly productive packaging lines

Details Highly productive packaging lines Highly productive packaging lines

2005-03-29

2005-03-29

Horlick, Kenneth R. (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S252300, C435S254110, C435S320100, C536S023100

Reexamination Certificate

active

06872528

ABSTRACT:
The invention concerns a packaging eukaryotic cell for the production of defective infections viruses carrying a transgene, characterized in that it is deficient in one cell function essential to its growth, in particular in the presence of a selection culture medium, the function being capable of being restored by the expression of an exogenous sequence introduced in the cell: either with a vector carrying transcomplementing functions of packaging cells; or with a vector carrying a transgene, and enabling the selection in a selective medium of cells carrying the said exogenous sequence.

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