Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-01-05
2000-04-04
Guzo, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 72, 435 29, 435 912, 435455, 435325, 4352523, 43525411, 43525421, 4352542, C12Q 102, C12Q 168
Patent
active
060460024
ABSTRACT:
The invention features methods for identifying gene products that mediate a phenotype, such as drug resistance or sensitivity, as well as methods for identifying new bioactive compounds, by detecting differences in sensitivity of growth rate between host cells that differ in target gene product dosage (e.g., two copies of a target gene product-encoding sequence compared to one copy).
REFERENCES:
patent: 5569588 (1996-10-01), Ashby et al.
DeRisi et al., "Use of a cDNA microarray to analyse gene expression patterns in human cancer" Nat Genet (Dec. 1996) 14(4):457-460.
Forozan et al., "Genome screening by comparative genomic hybridization" Trends Genet (Oct. 1997) 13(10):405-409.
Heller et al., "Discovery and analysis of inflammatory disease-related genes using cDNA microarrays" Proc Natl Acad Sci USA (Mar. 1997) 94(6):2150-2155.
DeRisi et al., "Exploring the metabolic and genetic control of gene expression on a genomic scale" Science (Oct. 1997) 278(5338):680-686.
Lashkari et al., "Yeast microarrays for genome wide parallel genetic and gene expression analysis" Proc Natl Acad Sci USA (Nov. 1997) 94(24):13057-13062.
Schuler et al., "A gene map of the human genome" Science (Oct. 1996) 274(5287):540-546.
Fraser et al., "The minimal gene complement of Mycoplasma genitalium" Science (Oct. 1995) 270(5235):397-403.
Fleischmann et al., "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd" Science (Jul. 1995) 269(5223):496-512.
Schena et al., "Quantitative monitoring of gene expression patterns with a complementary DNA microarray" Science (Oct. 1995) 270(5235):467-470.
Schena et al., "Parallel human genome analysis: microarray-based expression monitoring of 1000 genes" Proc Natl Acad Sci USA (Oct. 1996) 93(20):10614-10619.
Shalon et al., "A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization" Genome Res (Jul. 1996) 6(7):639-645.
Shoemaker et al., "Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular barcoding strategy " Nature Genetics (Dec. 1996) 14:450-456.
Gossen et al., "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters" Proc Natl Acad Sci USA (Jun. 1992) 89:5547-5551.
Palmer, "High throughput screening on a low budget" Nature Biotechnology (Apr. 1996) 14:513-516.
Liu et al., "Construction of a GAL1-Regulated Yeast cDNA Expression Library and Its Application to the Identification of Genes Whose Overexpression Causes Lethality in Yeast" Genetics (Nov. 1992) 132:665-673.
Rine et al., "Targeted selection of recombinant clones through gene dosage effects" Proc Natl Acad Sci USA (Nov. 1983) 80:6750-6754.
Rine, "Gene Overexpression in Studies of Saccharomyces cerevisiae" Methods in Enzymology (1991) 194;239-251.
Stewart et al., "Regulation of Gene Activity by Dosage Compensation at the Chromosomal Level in Drosophila" Genetics (Apr. 1975) 79:635-647.
Goffeau, et al., "Life with 6000 Genes," Science 274:546-567 (Oct. 25, 1996).
Davis Ron
Giaever Guri N.
Shoemaker Dan
Francis Carol L.
Guzo David
The Board of Trustees of the Leland Stanford Junior University
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