Highly packed polycationic ammonium, sulfonium and phosphonium l

Details Highly packed polycationic ammonium, sulfonium and phosphonium l Highly packed polycationic ammonium, sulfonium and phosphonium l

1998-11-06

2000-08-29

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

424 121, 424450, 435829, 514 2, 514 19, 514 77, 514170, 514171, 51425212, 544336, 544357, 544358, A61K 31495, C07D24104

Patent

active

061109169

ABSTRACT:
The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.

REFERENCES:
patent: 2654785 (1953-10-01), Miescher et al.
patent: 2867665 (1959-01-01), Dornfeld
patent: 3324182 (1967-06-01), DeBrunner et al.
patent: 3369905 (1968-02-01), Jones et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5091576 (1992-02-01), Bergeron
patent: 5171678 (1992-12-01), Behr et al.
patent: 5208036 (1993-05-01), Eppstein et al.
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5334761 (1994-08-01), Gebeyehu et al.
patent: 5635487 (1997-06-01), Wolff et al.
patent: 5674908 (1997-10-01), Haces et al.
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5744335 (1998-04-01), Wolff et al.
patent: 5834439 (1998-11-01), Haces et al.
patent: 5861397 (1999-01-01), Wheeler
Budker, V. et al. (1997), "Protein/Amphipathic Polyamine Complexes Enable Highly Efficient Transfection with Minimal Toxicity," BioTechniques 23(1):139-147.
Barthel, F. et al. (1993), "Gene Transfer Optimization with Lipospermine-Coated DNA," DNA and Cell Biology 12(6):553-560.
Loeffler, J-P et al. (1993), "Gene Transfer into Primary and Established Mammalian Cell Lines with Lipopolyamine-Coated DNA," Meth. Enzymol. 217:599-618.
Zhou, X. et al. (1991), "Lipophilic polylysines mediate efficient DNA transfection in mammalian cells," Biochim. Biophys. Acta 1065:8-14.
Duzgunes, N. et al. (1989), "Fusion of Liposomes Containing a Novel Cationic Lipid, N-[2-3-(Dioleyloxy)propyl]-N,N,N-trimethylammonium: Induction by Multivalent Anions and Asymmetric Fusion with Acidic Phospholipid Vesicles," Biochem. 28:9179-9184.
Behr, J-P et al. (1989), "Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA," Proc. Natl. Acad. Sci. USA 86:6982-6986.
Felgner, P.L. et al. (1987), "Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure," Proc. Natl. Acad. Sci. USA 84:7413-7417.
Weinstock, L.T. et al. (1981), "Synthesis of New Polyamine Derivatives for Cancer Chemotherapeutic Studies," J. Pharm. Sci. 70(8):956-959.
Hetschko, M. and Gosselck, J. (1972), "Reaktionen von Sulfoniumsalzen DES 1,3-Dithiolans und Seiner 2,2-Substitutionsprodukte," Tetrahedron Lett. 17:1691-1692.

Affiliated with

Also associated with

Rating

Highly packed polycationic ammonium, sulfonium and phosphonium l does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Highly packed polycationic ammonium, sulfonium and phosphonium l, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Highly packed polycationic ammonium, sulfonium and phosphonium l will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1250083