Highly lipophilic Camptothecin derivatives

Details Highly lipophilic Camptothecin derivatives Highly lipophilic Camptothecin derivatives

1998-10-20

2000-05-02

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

546 48, 546 14, 514283, A61K 314745, C07D49122, A61P 3500

Patent

active

060573031

ABSTRACT:
Derivatives of Camptothecin are disclosed, particularly derivatives having multiple substitutions at the `A`, `B` and `E` rings thereof. The novel compounds are useful in treating a wide variety of susceptible tumors and are potent inhibitors of Topoisomerase I.

REFERENCES:
patent: 4446322 (1984-05-01), Stein
patent: 4820815 (1989-04-01), Miller
patent: 5726181 (1998-03-01), Hausheer
patent: 5731316 (1998-03-01), Cao
Bundgaard H. Design of Prodrugs. Elsevier. Amsterdam-New York-Oxford. pp. 1-3, 1985.
Greene TW and Wuts PGM. Protective Groups in Organic Synthesis. Second Edition. John Wiley & Sons, Inc. New York./Chichester/Brisbane/Toronto/Singapore. pp. 12, 13, 1991.

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