Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-10-26
2000-02-22
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 48, C07D49122, A61K 31475
Patent
active
060280786
ABSTRACT:
Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
REFERENCES:
patent: 5633260 (1997-05-01), Hausheer et al.
Haridas Kochat
Hausheer Frederick H.
Murali Dhanabalan
Petluru Pavankumar N. V.
Reddy Dasharatha
BioNumerik Pharmaceuticals, Inc.
Dodd Thomas J.
Morris Patricia L.
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