Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-10-25
2005-10-25
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C435S091330, C435S091400, C435S235100, C424S199100
Reexamination Certificate
active
06958237
ABSTRACT:
Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus expression vectors of improved stability for the expression of live, attenuated togavirus and a foreign gene, based on the nucleic acid sequence of an infectious rubella virus clone and contain a togavirus non-structural protein open reading frame; an expression element for expression of a foreign gene; a foreign gene or a multiple cloning site for insertion of a foreign gene; an expression element for the expression of the live, attenuated togavirus; and a togavirus structural protein open reading frame. The expression element is either a subgenomic promoter or an internal ribosome entry site (IRES). Administration of the vector as an immunization agents is useful for the induction of immuity against the togavirus, the foreign gene, or both.
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Abernathy Emily S.
Frey Teryl K.
Pugachev Konstantin V.
Tzeng Wen-Pin
Georgia State Univesity Research Foundation, Inc.
Kilpatrick & Stockton LLP
Mosher Mary E.
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