Highly fluorinated, chloro-substituted organic compound-containi

Details Highly fluorinated, chloro-substituted organic compound-containi Highly fluorinated, chloro-substituted organic compound-containi

1991-12-12

1995-04-04

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

252312, 252314, 424 5, 424 9, 514757, 514832, 514942, 514943, A61K 3102, A61K 4300, A61K 4904, B01J 1300

Patent

active

054035759

ABSTRACT:
This invention relates to compositions comprising highly fluorinated, chloro-substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of making and using them. More particularly, this invention relates to emulsions comprising those highly fluorinated, chloro-substituted organic compounds. These novel emulsions have various medical and oxygen transport applications. They are especially useful medically as contrast media, for various biological imaging modalities such as nuclear magnetic resonance, ultrasound, x-ray, computed tomography, .sup.19 F-magnetic resonance imaging, and position emission tomography, as oxygen transport agents or "artificial bloods," in the treatment of heart attack, stroke, and other vascular obstructions, as adjuvants to coronary angioplasty and in cancer radiation treatment and chemotherapy.

REFERENCES:
patent: 2055083 (1936-09-01), Klein et al.
patent: 2490764 (1949-12-01), Benning et al.
patent: 3456024 (1969-07-01), Loree et al.
patent: 3778381 (1973-12-01), Rosano et al.
patent: 3793450 (1974-02-01), Schnell
patent: 3823091 (1974-07-01), Samejima et al.
patent: 3911138 (1975-10-01), Clark, Jr.
patent: 3914294 (1975-10-01), Bernstein et al.
patent: 3942527 (1976-03-01), Li
patent: 3958014 (1976-05-01), Watanabe et al.
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 3975512 (1976-08-01), Long, Jr.
patent: 3989843 (1976-11-01), Chabert et al.
patent: 3993581 (1976-11-01), Yokoyama et al.
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4073943 (1978-02-01), Wretlind et al.
patent: 4105798 (1978-08-01), Moore et al.
patent: 4110474 (1978-08-01), Lagow et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4252827 (1981-02-01), Yokoyama et al.
patent: 4285928 (1981-08-01), Wada et al.
patent: 4325972 (1982-04-01), Geyer et al.
patent: 4366169 (1982-12-01), White
patent: 4395393 (1983-07-01), Schmolka
patent: 4397870 (1983-08-01), Sloviter
patent: 4423061 (1983-12-01), Yokoyama et al.
patent: 4423077 (1983-12-01), Sloviter
patent: 4425347 (1984-01-01), Yokoyama et al.
patent: 4443480 (1984-04-01), Clark, Jr.
patent: 4446154 (1984-05-01), Osterholm
patent: 4452818 (1984-06-01), Haidt
patent: 4461717 (1984-07-01), Moore
patent: 4486417 (1984-12-01), Sugimoto et al.
patent: 4497829 (1985-02-01), Sloviter
patent: 4526969 (1985-07-01), Yokoyama et al.
patent: 4534978 (1985-08-01), Yokoyama et al.
patent: 4542147 (1985-09-01), Yokoyama et al.
patent: 4562183 (1985-12-01), Tatlow et al.
patent: 4569784 (1986-02-01), Moore
patent: 4591599 (1986-05-01), Yokoyama et al.
patent: 4599343 (1986-07-01), Yokoyama et al.
patent: 4657532 (1987-04-01), Osterholm
patent: 4686024 (1987-08-01), Scherer, Jr. et al.
patent: 4722904 (1988-02-01), Feil
patent: 4833274 (1989-05-01), Caporiccio et al.
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4866096 (1989-09-01), Schweighardt
patent: 4868318 (1989-09-01), Scherer, Jr. et al.
patent: 4895876 (1990-01-01), Schweighardt
patent: 4990283 (1991-02-01), Visca et al.
patent: 5093432 (1992-03-01), Bierschenk et al.
patent: 5171755 (1992-12-01), Kaufman et al.
L. S. Chen and G. J. Chen, "Reaction of Phosphorus Pentachloride With Perhalo Carbonyl-Containing Compounds", J. Fluor. Chem., 42, pp. 371-387 (1989) [Chen and Chen].
Q.-Y. Chen and Z.-M. Qiu, "Fluoroalkylation and Fluoroalkoxylation. Magnesium Single-Electron-Transfer Induced Synthesis of 2-Fluoroalkylpyrroles", J. Fluor. Chem., 39, pp. 288-292 (1988) ["Chen"].
L. C. Clark et al., "Emulsions of Perfluorinated Solvents for Intravascular Gas Transport", Fed. Proc., 34, pp. 1468-77 (1975) ["Clark et al."].
D. E. Hammerschmidt and G. M. Vercelloti, "Limitation of Complement Activation by Perfluorocarbon Emulsions: Superiority of Lecithin Emulsified Preparations", Chemical Abstracts, vol. 109, Abstract 197120n (1988) ["Hammerschmidt and Vercelloti"].
R. N. Haszeldine, "The Synthesis of Fluorocarbons and of Fully Fluorinated Iodo-, Bromo-, and Chloro-alkanes", in Reactions of Fluorocarbon Radicals, Part XII, pp. 3761-3768 (1953) (abstract No. 769) ["Haszeldine"].
R. Jeppsson, "Comparison of Pharmacological Effects of Some Local Anaesthetic Agents when using Water and Lipid Emulsion as Injection Vehicles", Acta Pharmacol. et Toxicol., 36, pp. 299-311 (1975) [Jeppsson I].
R. Jeppsson, "Parabolic Relationship between Lipophilicity and Biological Activity of Aliphatic Hydrocarbons, Ethers and Ketones after Intravenous Injections of Emulsion Formulations into Mice", Acta Pharmacol. et Toxicol., 37, pp. 56-64 (1975) [Jeppsson II].
R. Jeppsson and S. Ljungberg, "Anticonvulsant Activity in Mice of Diazepam in an Emulsion Formulation for Intravenous Administration", Acta Pharmacol. et Toxicol., 36, pp. 312-320 (1975) [Jeppsson and Ljungberg].
R. Jeppsson and S. Rossner, "The Influence of Emulsifying Agents and of Lipid Soluble Drugs on the Fractional Removal Rate of Lipid Emulsions from the Blood Stream of the Rabbit", Acta Pharmacol. et Toxicol., 37, pp. 134-144 (1975) [Jeppsson and Rossner].
R. Jeppsson and G. I. Schoefl, "The Ultrastructure of Lipid Particles in Emulsions Prepared with Various Emulsiifiers", Aust. J. Exp. Biol. Medd. Sci., 52, pp. 697-702 (1974) [Jeppsson and Schoefl].
R. Jeppsson an B. Sjoberg, "Compatibility of Parenteral Nutrition Solutions when mixed in a Plastic Bag", Clin. Nutr., 2, pp. 149-158 (1984) [Jeppsson and Sjoberg].
R. Jeppsson et al., "Particle Size Distribution of a Fluorochemical Emulsion", in Proceedings of the HS Symposium on Perfluorochemicals in Medicine and Biology, Huddinge, Sweden, Apr. 28-29, 1977, V. Novakova et al., eds., pp. 108-113 (1977) [Jeppsson et al.].
S. Ljungberg and R. Jeppsson, "Intravenous Injection of Lipid Soluble Drugs", Acta Pharm. Suecica, 7, pp. 435-40 (1970) [Ljungberg and Jeppsson].
H. Ohyanagi and Y. Saitoh, "Development and Clinical Application of Perfluorochemical Artificial Blood", Int. J. Artificial Organs, 9, pp. 363-368 (1986) [Ohyanagi and Saitoh].
E. P. Wesseler et al., "The Solubility of Oxygen In Highly Fluorinated Liquids", J. Fluor. Chem., 9, pp. 137-146 (1977) [Wesseler].
A. Wretlind, "Current Status of Intralipid an Other Fat Emulsions", in Fat Emulsions Parenter, Nutr., H.-C. Meng et al., eds., American Medical Association, Chicago, Ill., pp. 109-122 (1976) [Wretlind I].
A. Wretlind, "Development of Fat Emulsions", J. Parenter, Enteral Nutr., 5, pp. 230-235 (1981) [Wretlindd II].
K. Yokoyama et al., "A Perfluorochemical Emulsion as an Oxygen Carrier", Artificial Organs, 8, pp. 34-40 (1984) [Yokoyama et al.].
A. Y. Zapevalov et al., "Synthesis and Reactions Of Oxygen-Containing Organofluorine Compounds", J. Org. Chem. (trans.), 14(2), pp. 259-262 (1978) (CA 88: 190026a) [Zapevalov].
CA 110: 75218a.

Affiliated with

Also associated with

Rating

Highly fluorinated, chloro-substituted organic compound-containi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Highly fluorinated, chloro-substituted organic compound-containi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Highly fluorinated, chloro-substituted organic compound-containi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2379387