Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Recovery or purification
Patent
1997-04-15
2000-06-27
Lankford, Jr., Leon B.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Recovery or purification
4352351, 210660, L12N 702
Patent
active
060805714
ABSTRACT:
This invention is directed to a continuous process for producing viral particles comprising providing in a perfused growth medium a population of viable virally infected non-lytic cells, and removing medium containing said cells at a rate to maintain the steady-state log-phase growth of cells remaining in said perfused growth medium. The invention is also directed to a process for purifying retroviral particles comprising passing a solution comprising the retroviral particles and contaminants through an anion exchange resin, and eluting the retroviral particles from the resin.
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Gore Richard S.
Harter James J.
Prior Christopher P.
Weber David M.
Lankford , Jr. Leon B.
The Immune Response Corporation
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