Highly cross-linked polymeric supports

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C08F 1800

Patent

active

056567073

ABSTRACT:
A polymer useful as a solid support for a variety of applications is provided. The polymer is prepared from a composition comprising at least one type of olefinic monomer and a multifunctional oxyethylene-containing meth(acrylate) crosslinker of the following formula (I): ##STR1## wherein: (a) R.sup.1, R.sup.2, and R.sup.3 are each independently hydrogen or a methyl group;

REFERENCES:
patent: 4908405 (1990-03-01), Bayer et al.
patent: 5117009 (1992-05-01), Barany
patent: 5196566 (1993-03-01), Barany et al.
patent: 5235028 (1993-08-01), Barany et al.
patent: 5352756 (1994-10-01), Meldal
patent: 5403750 (1995-04-01), Braatz et al.
NIH Grant No. GM 42722 (Abstract).
NIH Grant No. GM 51628 (Abstract).
Albericio et al., "Preparation and Application of the 5-(4-(9-Fluorenylmethyloxycarbonyl)aminomethyl-3,5-dimethoxyphenoxy)-valer ic Acid (PAL) Handle for the Solid-Phase Synthesis of C-Terminal Peptide amides under Mild Conditions," J. Org. Chem., 55, 3730-3743 (1990).
Arshady et al., "Peptide Synthesis. Part 1. Preparation and Use of Polar Supports based on Poly(dimethylacrylamide)," J. of Chem. Soc. Perkin I, 2, 529-537 (1981).
Arshady et al., "Preparation of polymer nano- and microspheres by vinyl polymerization techniques," J. Microencapsulation, 5(2), 101-114 (1988).
Atherton et al., "Racemisation of Activated, Urethane-protected Amino-acids by p-Dimethyl-aminopyridine. Significance in Solid-phase Peptide Synthesis," J.C.S. Chem. Comm., 7, 336-337 (1981).
Barany et al., "Solid-phase peptide synthesis: a silver anniversary report," Int. J. Peptide Protein Res., 30, 705-739 (1987).
Barany et al., "Novel polyethylene glycol-polystyrene (PEG-PS) graft supports for solid-phase peptide synthesis," Peptides, 267-268 (1992).
Barany et al., The Peptides, 2, Bookcover, Copyright Page, Table of Contents, Chapter 1 Table of Contents (1979).
Bayer et al., "Immobilized Polyoxyethylene, A New Support for Peptide Synthesis," Peptides: Structure and Function, Eds.: V.J. Hruby et al., Proceedings of the 8th American Peptide Symposium, 87-09 (1983).
Columbo, "New Poly(Ethylene Glycol) Supports for the Liquid-Phase Synthesis of Protected Hydrazides," Tetrahedron Letters, 22(41), 4129-4132 (1981).
Drumheller et al., "Multifunctional Poly(ethylene glycol) Semi-Interpenetrating Polymer Networks as Highly Selective Adhesive Substrates for Bioadhesive Peptide Grafting," Biotechnology and Bioengineering, 43, 772-780 (1994).
Drumheller et al., "Polymer Networks with Grafted Cell Adhesion Peptides for Highly Biospecific Cell Adhesive Substrates," Polymeric Networks for Biospecific Substrates, 380-388 (1994).
Drumheller et al., "Densely Crosslinked polymer networks of poly(ethylene glycol) in trimethylopropane triacrylate for cell-adhesion-resistant surfaces," Journal of Biomedical Research, 29, 207-215 (1995).
Englebretsen et al., "Fmoc SPPS using Perloza.TM. beaded cellulose," Int. J. Peptide Protein Res., 43, 546-554 (1994).
Hargitai et al., "Polymer-bound chiral polymers for use in enantiomer separations," Journal of Chromatography, 540, 145-155 (1991).
Hargitai et al, "Functionalized polymer particles for chiral separation," J. Chromatogr., 630, 79-94 (1993).
Hellerman et al., "Poly(ethylene glycols)s Grafted onto Crosslinked Polystrenes, 2.sup.a), Multidetachably Anchored Polymer Systems for the Synthesis of Solubilized Peptides," Makromol. Chem., 184, 2603-2617 (1983).
Hjertberg, ".sup.13 C CP-MAS NMR Study on Content and Mobility of Double Bonds in Poly(trimethylopropane trimethacrylate)," Macromolecules, 23(12), 3080-3087 (1990).
Kanda et al., "Synthesis of polyamide supports for use in peptide synthesis and as peptide-resin conjugates for antibody production," Int. J. Peptide Protein Res., 38, 385-391 (1991).
Kempe, Chiral Recognition, "Studies on chiral discrimination in enzymatic peptide synthesis and non-covalent molecular imprinting," 1-154 (1994).
Kolarz et al., "Porous copolymers of trimethylolpropane triacrylate and acrylonitrile", Makromol. Chem., 194, 1299-1306 (1993).
Meldal et al., "Pega: A Flow Stable Polyethylene Glycol Dimethyl Acrylamide Copolymer for Solid Phase Synthesis," Tetrahedron Lett., 33(21), 3077-3080 (1992).
Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide," J. Am. Chem. Soc., 85, 2149-2154 (1963).
Reinholdsson et al., "Preparation and properties of porous particles from trimethylolpropane trimethacrylate," Applied Macromolecular Chem. and Phys., 192, 113-132 (1991).
Reinholdsson, New types of functional composite particles based on poly(tri-methylol propane tri-methacrylate), 1-28 (1991).
Reinholdsson, "Poly(tri-methyl propane tri-methacrylate) particles with acid chloride functionality-a convinient entry to support materials for catalysis and chromatography," New types of functional composite particles bases on poly(tri-methylol propane tri-methacrylate), 1-23 (1991).
Reinholdsson, "Poly(tri-methylol propane tri-methacrylate) particles with phosphine functionality--a new type of support for metal phosphine complex catalysts," New Types of functional composite particles based on poly(tri-methylol propane tri-methacrylate), 1-23 (1991).
Renil et al., "Gel-Phase Peptide Synthesis on a New High-Capacity Tetraethyleneglycol eiacrylate-Crosslinked Polystyrene Support: Synthesis of Pardaxin 16-33," Tetrahedron, 50(22), 6681-6688 (1994).
Rosenberg, et al., "Macroporous Gels. 3. Copolymerization of Trimethylolpropane Trimethacrylate and Methacrylate in Toluene or Ethyl Acetate," Macromolecules, 20, 1522-1526 (1987).
Sarin et al., "Properties of Swollen Polymer Networks. Solvation and Swelling of Peptide-Containing Resins in Solid-Phase Peptide Synthesis," J. Am. Chem. Soc., 102, 5463-5470 (1980).
Sawicki, "Phase Transfer Catalysts Polyethylene Glycols Immobilized onto Metal Oxide Surfaces," Tetrahedron Letters, 23(22), 2249-2252 (1983).
Small et al., "Design and Application of a New Rigid Support for High Efficiency Continuous-flow Peptide Synthesis," J.C.S. Chem. Commun., No. 21, 1589-1696 (1989).
Stewart et al., "Polystyrene-Based Solid Phase Peptide Synthesis: The State of the Art," Innovation and Perspectives in Solid Phase Synthesis: Peptides, Polypeptides, and Oligonucleotides, Macro-organic and Catalysts, Ed.: R. Epton, SPCC UK Ltd., 1-9 (1990).
Zaplisky et al., "Preparation and Use of an Aminoethyl Polyethylene Glycol-Crosslinked Polystyrene Graft Resin Support for Solid-Phase Peptide Synthesis," Peptides: Structure and Function, Eds: V.J. Hruby et al., Proceedings of the 9th American Peptide Symposium, 257-260 (1985).
Zaplisky et al., "Preparation and applications of polyethylene glycol-polysytrene graft resin supports for solid-phase peptide synthesis," Reactive Polymers, 22, 243-258 (1994).
"Aqueous Resin Dispersions for Coatings and Textile Bording" Yoshiichi et al, JP03152168, Jun. 28, 1991 pp. 115-117 and 2 (inked) (Computer Generated).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Highly cross-linked polymeric supports does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Highly cross-linked polymeric supports, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Highly cross-linked polymeric supports will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-161279

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.