Highly concentrated immunoglobulin preparation and method for it

Details Highly concentrated immunoglobulin preparation and method for it Highly concentrated immunoglobulin preparation and method for it

1994-12-20

1997-03-04

Eisenschenk, Frank C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303891, 4241301, C07K 1600, A61K 39395

Patent

active

056080387

ABSTRACT:
A stable, highly concentrated intravenously tolerable immunoglobulin preparation is described having an immunoglobulin content from 13.5 to 17.5% (w/v), an osmolarity from 250 to 600 mOs/l and a viscosity of no more than 9 cP. The immunoglobulin preparation possesses an exceptional imperishability and also is used as a highly concentrated preparation without problems due to its low viscosity.

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patent: 4499073 (1985-02-01), Tenold
patent: 5122373 (1992-06-01), Eibl et al.
patent: 5248767 (1993-09-01), Muller et al.
Endobulin, Functionally Intact Immunoglobulin G For Intravenous Administration Aggregate Free, Virus Inactivated, Immuno AG (Feb. 1988).
Schiff et al., Rapid Infusion of Sandoglobulin in Patients with Primary Humoral Immunodeficiency, J. Allergy Clin. Immunol., 1991, vol. 88, pp. 61-67.
Herrera et al., Immunoglobulin Composition of Three Commercially Available Intravenous Immunoglobulin Preparations, J. Allergy Clin. Immunol., 1989, vol. 84, pp. 556-561.

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