Highly bioavailable coenzyme Q-10 cyclodextrin complex

Details Highly bioavailable coenzyme Q-10 cyclodextrin complex Highly bioavailable coenzyme Q-10 cyclodextrin complex

2006-04-18

2006-04-18

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S435000, C424S451000, C424S489000

Reexamination Certificate

active

07030102

ABSTRACT:
The present invention is based on the unexpected discovery that CoQ-10 can be made commercially in a highly bioavailable form suitable for topical, sublingual formulations, or for oral ingestion. One such bioavailable form is a water dispersible freeze-dried CoQ-10/γ-cyclodextrin complex. Complexation in general with γ- or α-cyclodextrin improved the cellular uptake of CoQ-10 as compared to water dispersible liposomal or micellar forms of CoQ-10. Thus, the present invention includes a highly bioavailable CoQ-10/cyclodextrin complex for use in the nutritional supplement, oral care, and pharmaceutical industry.

REFERENCES:
patent: 6461593 (2002-10-01), Hanioka et al.
patent: 6569463 (2003-05-01), Patel et al.
patent: 2003/0012774 (2003-01-01), Moldenhauer et al.
patent: 59047202 (1984-03-01), None
patent: 60089442 (1985-05-01), None
Gattuso et al. Synthetic Cyclic Oligosaccharides. Chem Rev. 1998, 98, pp. 1919-1958.
“Cyclodextrins as carriers of cholesterol and fatty acids in cultivation of mycoplasmas”, Appl. Envr. Microbiol., 59: 547-551, 1993).
“Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug”, Eur. J. Pharm. Biopharm., 51: 221-225, 2001.
“Effect of inclusion complexation with cyclodextrins on photostability of nifedipine in solid state”, Int. J. Pharm., 243: 107-17, 2002.
“Enhancement of dissolution and oral bioavailabilty of gliquidone with hydroxypropyl-beta-cyclodextrin”, Pharmacia, 2003: 58 (11):807-10.
Physiocochemcial characterization and in vitro dissolution behavior of nicardipine hydrochloride inclusion compounds, Eur J Pharm Sci. Feb. 2002; 15(1): 79-88.
Effect of the hydrophobic nature of triacetyl-b-cyclodextrin on the complexation with nicardipine hydrochloride: physicochemical and dissolution properties of the kneaded and spray-dried complex, Chem Pharm Bull (Tokyo). Dec. 2002; 50 (12): 1597-602.
“Preparation and characterization of albendazole beta-cyclodexrin complexes”, Drug Dev Ind Pharm. Dec. 1999; 25(12):12418.
“Influence of the preparation method on the physicochemical properties of ketoprofen-cyclodextrin binary systems”, Int J Pharm. Mar. 1, 1999; 179(1): 117-28.
“Influence of the preparation method on the physicochemical properties of binary systems of econazole with cyclodextrins”, Int J Pharm. Dec. 20, 1999; 193(1): 85-95.
“Review-Cyctodextrins in topical drug formulations: Theory and Practice”, Int. J. Pharm, 225: 15-30, 2001.

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