High-voltage biological macromolecule transfer and cell fusion s

Details High-voltage biological macromolecule transfer and cell fusion s High-voltage biological macromolecule transfer and cell fusion s

1984-12-21

1987-05-05

Cohan, Alan

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

4351723, 935 52, 328158, C12M 100

Patent

active

046632921

ABSTRACT:
A high-voltage biological macromolecule transfer and cell fusion system for transforming a low input voltage into a high-voltage discharge output. The system comprises voltages source means, a frequency source means, a burst control means, a cycle control means, a pulse generating means, a pulse control means, and a high-voltage discharge generating means. The voltages source means is adapted to transform the generally low input voltage into a system-enabling control signal, a direct-current base voltage, and a generally low-voltage direct-current system voltage. The frequency source means generates system-enabling control pulses. The burst control means is provided to control the burst time of the high-voltage discharge output. The cycle control means is adapted to control the number of cycles in the high-voltage discharge output. The pulse generating means generates the pulses that evolve into the high-voltage discharge output. The pulse control means is adapted to control the number of pulses within each cycle of the high-voltage discharge output. The burst control means, the cycle control means, the pulse generating means and the pulse control means produce a composite signal. The high-voltage discharge generating means is provided for transforming the low-voltage system voltage and the composite signal into the high-voltage discharge output.

REFERENCES:
patent: 3659226 (1972-04-01), Angeleri
patent: 3758873 (1973-09-01), Miller
W. Anderson, "Prospect for Human Gene Therapy," 226 Science 401 (Oct. 26, 1984).
G. Scangos and F. Ruddle, "Mechanisms and Applications of DNA-Mediated Gene Transfer in Mammalian Cells--a review," 14 Gene 1 (1981).
U. Zimmerman and J. Greyson, "Electric Field-Induced Cell Fusion," Biotechniques (Sep./Oct. 1983).
T. Wong and E. Neumann, "Electric Field Mediated Gene Transfer," 107 Biochem. & Biophys. Res. Comm., 584-587 (Jul. 30, 1982).

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