Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1990-01-29
1992-11-17
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, 2041828, 2041832, G01N 2726, B01D 5702
Patent
active
051640554
ABSTRACT:
A supported, substantially uniform matrix for use in electric field-induced separation of molecular components in a sample. The matrix is prepared by forming a viscoelastic polymer matrix and pumping the matrix into a capillary or preparative-scale tube. The polymer type, concentration, and molecular weight are selected to optimize separation of protein or nucleic acid components. The matrix can be expelled from the tube, after fractionation, for analysis and/or recovery of fractionated components.
REFERENCES:
S. Hjerten et al "High-Performance Electrophoresis of Acidic and Basic Low-Molecular-Weight Compounds and Proteins in the Presence of Polymers and Neutral Surfactants" Journal of Liquid Chromatography, 12(13) 2471-2499 [1989].
N. A. Guzman et al "Capillary Electrophoresis: A New Era in Microseparations" BioPharm Jan. 1989 pp. 22-37.
S. W. Compton & R. G. Brownlee "Capillary Electrophoresis" Biotechniques, vol. 6 No. 5 (1988) pp. 432-440.
D. Tietz et al "Electrophoresis on uncrosslinked polyacrylamide: Molecular sieving and its potential applications" Electrophoresis, 7 (1986) 217-220.
B. J. Radola "Ultra-thin-layer isoelectric focusing" in Electrophoretic Techniques, Simpson & Whittaker, eds. (1983) 106-109.
Applied Biosystems Inc.
Dehlinger Peter J.
Niebling John
Smith Joseph A.
Starsiak Jr. John S.
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