High transgene expression of a pseudotyped adeno-associated...

Details High transgene expression of a pseudotyped adeno-associated... High transgene expression of a pseudotyped adeno-associated...

2003-05-01

2009-12-29

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Virus or bacteriophage

C424S093200, C536S023100, C536S023720, C536S024100

Reexamination Certificate

active

07638120

ABSTRACT:
The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permits selective targeting of desired cells.

REFERENCES:
patent: 6491907 (2002-12-01), Rabinowitz et al.
Eck et al., 1996, Goodman & Gilman's The Pharmacological Basis of Therapeutics, McGraw-Hill, New York, p. 77-101.
Gorecki, 2001, Expert Opin. Emerging Drugs, 6(2): 187-198.
Davidson et al., 2000, PNAS, vol. 97, No. 7, p. 3428-3432.
Rabinowitz et al., 2000, Virology, vol. 278, p. 301-308.
Deonarain, M., 1998, Expert Opin. Ther. Pat., vol. 8, pp. 53-69.
Verma et al., Sep. 1997, Nature, vol. 389, pp. 239-242.
Burger et al., 2005, Human Gene Therapy, vol. 16, p. 781-791.

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