High titer varicella-zoster immune globulin for intravenous admi

Details High titer varicella-zoster immune globulin for intravenous admi High titer varicella-zoster immune globulin for intravenous admi

1985-11-07

1987-05-12

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 85, 424 86, 424 89, 424101, 530389, 530390, 530830, 530388, A61K 3925

Patent

active

046651594

ABSTRACT:
Normal plasma from donors who have not been vaccinated with a varicella-zoster vaccine can be screened for higher than normal titers of naturally occurring antibody to varicella-zoster virus. Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune globulin. The product may be treated to render it suitable for intravenous injection. Patients with varicella-zoster infection or at risk to such infection, may receive the present product to raise serum titers of varicella-zoster antibody.

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Amer. J. Med., 124-127, Mar., 1984, Paryani et al.
J. Pediatrics, 105 (2), 200-205 (1984), Aug. Paryani et al.
J. Amer. Med. ASSN-251 (11), 1401, 1405, 1409 and 1413 (1984), Immunization Practices Advisory Commission.

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