High titer Pseudomonas immune serum globulin

Details High titer Pseudomonas immune serum globulin High titer Pseudomonas immune serum globulin

1983-06-17

1986-05-06

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 85, 424101, 530387, 530831, A61K 39395, A61K 3940, C07K 1500, C07K 300

Patent

active

045871213

ABSTRACT:
Normal plasma from donors who have not been vaccinated with a Pseudomonas vaccine or had a Pseudomonas infection can be screened for higher than normal titers of naturally occurring antibody to four of seven Fisher Immunotypes for Pseudomonas. Those plasmas with higher titers of such antibody can be pooled and fractionated to give hyperimmune serum globulin having high titers of antibody against all seven Fisher Immunotypes. The product may be treated to render it intravenously injectable and the so-prepared material is effective in treating patients with Pseudomonas infection.

REFERENCES:
patent: 2793203 (1957-05-01), Schultze et al.
patent: 4027010 (1975-04-01), Kiselen et al.
patent: 4120950 (1978-10-01), Homma
patent: 4285936 (1981-08-01), Peer et al.
patent: 4482483 (1984-11-01), Curry et al.
Chemical Abstracts, vol. 86, Abstract No. 68043x, 1977.
Chemical Abstracts, vol. 99, Abstract No. 191214z, 1983.
Chemical Abstracts, vol. 77, Abstract No. 99601w, 1972.

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