Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2006-01-17
2006-01-17
Lee, John R. (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S287000
Reexamination Certificate
active
06987263
ABSTRACT:
Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.
REFERENCES:
patent: 4507555 (1985-03-01), Chang
patent: 4840074 (1989-06-01), Jessop
patent: 5071547 (1991-12-01), Cazer et al.
patent: 5401963 (1995-03-01), Sittler
patent: 5872010 (1999-02-01), Karger et al.
patent: 5917184 (1999-06-01), Carson et al.
patent: 6012488 (2000-01-01), Nichols
patent: 6066848 (2000-05-01), Kassel et al.
patent: 6175112 (2001-01-01), Karger et al.
patent: 6191418 (2001-02-01), Hindsgaul et al.
patent: 6264892 (2001-07-01), Kaltenbach et al.
patent: 6296771 (2001-10-01), Miroslav
patent: 6316768 (2001-11-01), Rockwood et al.
patent: 6318157 (2001-11-01), Corso et al.
patent: 6369893 (2002-04-01), Christel et al.
patent: 6410915 (2002-06-01), Bateman et al.
patent: 6437345 (2002-08-01), Bruno-Raimondi et al.
patent: 6464866 (2002-10-01), Moon et al.
patent: 6532978 (2003-03-01), Müller-Kuhrt et al.
patent: 6547941 (2003-04-01), Kopf-Sill et al.
patent: 6580070 (2003-06-01), Cornish et al.
patent: 6581441 (2003-06-01), Paul
patent: 6586727 (2003-07-01), Bateman et al.
patent: 6613581 (2003-09-01), Wada et al.
patent: 6614030 (2003-09-01), Maher et al.
patent: 6649908 (2003-11-01), Apffel, Jr. et al.
patent: 6777670 (2004-08-01), Farnsworth
patent: 6827095 (2004-12-01), O'Connor et al.
patent: 6841774 (2005-01-01), Weiss
patent: 2002/0027197 (2002-03-01), Duholke et al.
patent: 2002/0036018 (2002-03-01), McNeely et al.
patent: 2002/0041827 (2002-04-01), Yager et al.
patent: 2002/0068366 (2002-06-01), LaDine et a.
patent: 2002/0158022 (2002-10-01), Huang et al.
patent: 2002/0189947 (2002-12-01), Paul et al.
patent: 2002/0199094 (2002-12-01), Strand et al.
patent: 2003/0089663 (2003-05-01), Petro et al.
patent: 2003/0089846 (2003-05-01), Cooks et al.
patent: 2003/0162304 (2003-08-01), Dority et al.
patent: 2003/0200794 (2003-10-01), Paul
patent: EP 1 106 244 (2001-06-01), None
patent: WO 98/09315 (1998-03-01), None
patent: WO 98/35376 (1998-08-01), None
patent: WO 00/72970 (2000-12-01), None
patent: WO 01/38865 (2001-05-01), None
patent: WO 02/30486 (2002-04-01), None
“Multi-Parallel-HPLC,” Web document published at: http://www.sepiatec.com/download/phplc.pdf, SEPIAtec GmbH, Louis-Blériot-Strasse 5 D-12487 Berlin Germany.
Figeys, Daniel et al.,Lab-on-a-Chip: A Revolution in Biological and Medical Sciences, “Analytical Chemistry,” May, 1, 2000.
Wachs, Timothy et al.,Electrospray Device for Coupling Microscale Separations and Other Miniaturized Devices with Electrospray Mass Spectrometry, “Analytical Chemistry,” vol.73, No. 3, Feb. 1, 2001, pp. 632-638.
Morrison, Denise et al.,An Evaluation of a Four-Channel Multiplexed Electrospray Tandem Mass Spectrometry for Higher Throughput Quantitative Analysis, “Analytical Chemistry,” vol. 74, No.8, Apr. 15, 2002, pp. 1896-1902.
Figeys, Daniel et al.,An Integrated Microfluidies-Tandem Mass Spectrometry System for Automated Protein Analysis, “Analytical Chemistry,” vol. 70, No. 18, Sep. 15, 1998, pp. 3728-3724.
Xue, Qifeng et al.,Multichannel Microchip Electrospray Mass Spectrometry, “Analytical Chemistry,” vol.69, No.3, Feb. 1, 1997, pp. 426-430.
Wagner, Knut et al.,An Automated On-Line Multidimensional HPLC System for Protein and Peptide Mapping with Integrated Sample Preparation, “Analytical Chemistry,” vol. 74, No.4, Feb. 15, 2002, pp. 809-820.
Xu, Rongda et al.,Application of Parallel Liquid Chromatography/Mass Spectrometry for High Throughput Microsomal Stability Screening of Compound Libraries, “Journal of the American Society for Mass Spectrometry,” 2002, 13, 155-165.
Van Pelt, Colleen K. et al.,A Four-Column Parallel Chromatography System for Isocratic or Gradient LC/MS Analyses, “Analytical Chemistry,” vol. 73, No. 3, Feb. 1, 2001, pp. 582-588.
Janiszewski, John S. et al.,A High-Capacity LC/MS System for the Bioanalysis of Samples Generated from Plate-Based Metabolic Screening, “Analytical Chemistry,” vol. 73, No. 7, Apr. 1, 2001, pp. 1495-1501.
Zhang, Bailin et al.,High- Throughput Microfabricated CE/ESI-MS: Automated Sampling from a Microwell Plate, “Analytical Chemistry,” vol. 73, No. 11, Jun. 1, 2001, pp. 2675-2681.
Tang, Keqi et al.,Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity, “Analytical Chemistry,” vol. 73, No. 8, Apr. 15, 2001, pp. 1658-1663.
Liu, Hanghui et al.,Development of Multichannel Devices with an Array of Electrospray Tips for High-Throughput Mass Spectrometry, “Analytical Chemistry,” vol. 72, No. 14, Jul. 15, 2000, pp. 3303-3310.
Yang, Liyu et al.,Evaluation of Four-Channel Multiplexed Electrospray Triple Quadrupole Mass Spectrometer for the Simultaneous Validation of LC/MS/MS Methods in Four Different Preclinical Matrixes, “Analytical Chemistry,” vol. 73, No. 8, Apr. 15, 2001, pp. 1740-1747.
“LCT wit MUX-technology,” Internet document from www.micromass.co.uk/systems/sysorg22.asp, Printed Jul. 19, 2002, date of origin unknown.
Xu, Rongda et al.,High-Throughput Mass-Directed Parallel Purification Incorporation a Muliplexed Single Quadrupole Mass Spectrometer, “Analytical Chemistry,” vol. 74, No. 13, Jul. 1, 2002, pp. 3055-3062.
Fang, Liling et al.,High-throughput liquid chromatography ultraviolet/mass spectrometric analysis of combinatorial libraries using an eight-channel multiplexed electrospray time-of-flight mass spectrometer, “Rapid Communications in Mass Spectrometry,” 2002, 16, 1440-1447.
Rohrbacher, Andreas et al.,Muliple-ion-beam time-of-flight mass spectrometer, Review of Scientific Instruments, vol. 72, No. 8, Aug. 2001,.
Abian, J.,The Coupling of Gas and Liquid Chromatography with Mass Spectrometry, “Journal of Mass Spectrometry,” 34, 157-168, (1999).
“HPLC: Micro LC/MS Analysis of Biological Samples,” Web publication; http://www.sge.com, Apr. 1, 1998.
Kameoka, Jun et al.,A Polymeric Microfluidic Chip for CE/MS Determination of Small Molecules, “Analytical Chemistry,” vol. 73, No. 9, May 1, 2001, pp. 1935-1941.
Yin, Hongfeng et al., “A polymeric microfluidic device with integrated mass-spectrometer interface,” Web publication, 2002.
Kim, Young Chan et al., “Rapid Sample Cleanup Microchip for Protein Analysis by Electrospray Ionization Mass Spectrometry,”Micro Total Analysis Systems, J.M. Ramsey and A. van den Berg (eds.), 2001, Kluwer Academic Publishers, the Netherlands, pp. 123-124.
Lazar, Lulia M. et al., “Microchip Integrated Analysis System for Electrospray Mass Spectrometric Analysis of Complex Peptide Mixtures,”Micro Total Analysis Systems, J.M. Ramsey and A. van den Berg. (eds.), 2001, Kluwer Academic Publishers, the Netherlands, pp. 219-221.
Killeen, Kevin et al., “Chip-MS: A Polymeric Microfluidic Device with Integrated Mass-Spectrometer Interface,”Micro Total Analysis Systems, J.M. Ramsey and A. van den Berg (eds.), 2001, K
Gamble Ronald C.
Hobbs Steven E.
O'Connor Stephen D.
Fernandez Kalimah
Gustafson Vincent K.
Nanostream, Inc.
LandOfFree
High throughput systems and methods for parallel sample... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with High throughput systems and methods for parallel sample..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High throughput systems and methods for parallel sample... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3600822