Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving luciferase
Reexamination Certificate
2008-04-08
2008-04-08
Gabel, Gailene Rio (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving luciferase
C435S001200, C435S002000, C435S003000, C435S007200, C435S008000, C435S040510, C435S040520, C435S374000, C435S375000, C435S376000, C435S377000, C435S384000, C435S385000, C435S386000, C435S387000, C435S388000, C435S392000
Reexamination Certificate
active
10059521
ABSTRACT:
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the growth of hematopoietic stem and progenitor cells and for identifying subpopulations thereof that are suitable for transplantation. The assay of the present invention is particularly useful for quality control and monitoring of the growth potential in the stem cell transplant setting and would provide improved control over the reconstitution phase of transplanted cells.
REFERENCES:
patent: 5328844 (1994-07-01), Moore
patent: 5580724 (1996-12-01), Alter
patent: 6440407 (2002-08-01), Bauer et al.
patent: 2002/0120098 (2002-08-01), Bell et al.
patent: WO 92/13063 (1992-08-01), None
patent: WO 94/17177 (1994-08-01), None
patent: WO 98/08537 (1998-03-01), None
patent: 98/21313 (1998-05-01), None
patent: WO 98/21313 (1998-05-01), None
patent: WO 98/28437 (1998-07-01), None
Crouch et al., The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity, Journal of Immunological Methods, 160: 81-88 (1993)).
Castello et al., AZT and IF-alpha in vitro effects on hematopoiesis: Protective in vitro activity of IL-1 and GM-CSF, Experimenta Hematology 23: 1367-1371 (1995)).
“Circannual Variations Of Cicadian Periodicity In Murine Colony-Forming Cells”; Aardal, Nils-Petter, Experimental Hematology, 12:61-67 (1984).
“Circadian Variations in Mouse Bone Marrow”; Aardal, N.P. & Laerum, O.D., Experimental Hematology, vol. 11, No. 9, pp. 792-801 (1983).
“Cyclic Hematopoiesis in Dogs: Studies of Erythoid Burst-forming Cells Confirm an Early Stem Cell Defect”; Abkowitz, Janis L., Holly, Richard D., Hammond, William P. IV, Experimental Hematology, 16:941-945 (1988).
“Hematopoietic Effects of Benzene Inhalation Assessed by Long-term Bone Marrow Culture”, Abraham, Nadar G., Environmental Health Perspectives, vol. 104, Supplement 6, pp. 1277-1282 (1996).
“Circadian cell cycle variations of erythro- and myelopoiesis in humans”; Abrahamsen, JF, Smaaland, R, Sothern, RB, Laerum OD, European Journal of Haematology, vol. 58, pp. 333-345 (1997).
“Circadian and seasonal variations of hematopoiesis in cord blood”; Baudoux, E., et al, Bone Marrow Transplantation, Supplement 1, S12, p. 22 (1998).
“Toxicity on Human Hemopoietic Progenitors of 2′-2′-Difluoro-2′Deoxycytidine (Gemcitabine)”; Botta, Marco, et al, Anticancer Research, vol. 18, pp. 1037-1042 (1998).
“Measurement of the ADP:ATP ratio in human leukaemic cell lines can be used as an indicator of cell viability, necrosis and apoptosis”; Bradbury, D.A. Simmons, T.D., Slater, K.J., Crouch, S.P.M., Journal of Immunological Methods 240, pp. 79-92 (2000).
“The Growth Of Mouse Bone Marrow Cells In Vitro”; Bradley, T.R., Metcalf, D, Aust. J. Experimental Biological Medical Science, 44, pp. 287-300 (1966).
“Cyclic oscillations of neutrophils, monocytes, and CD8-positive lymphocytes in a healthy subject”; Carulli, Giovanni, et al, Haematologica, vol. 85(4), pp. 447-448 (2000).
“Azidothymidine and interferon-α in vitro effects on hemotopoiesis: Protective in vitro activity of IL-1 and GM-CSF”; Castello, G, et al, Experimental Hematology 23, pp. 1367-1371 (1995).
“Hematotoxicity of 5-Fluorouracil-Leucovorin in a Setting of Adjuvant Chemotherapy”; Cerruti, Allessandro, et al, Anticancer Research 14, pp. 2163-2166 (1994).
“Chemopreventive Agent Resveratrol, a Natural Product Derived From Grapes, Triggers CD95 Signaling-Dependent Apoptosis in Human Tumor Cells”; Clement, M., et al, Blood, vol. 92, No. 3, pp. 996-1002 (1998).
“Idarubicinol myelotoxicity: a comparison of in vitro data with clinical outcome in patients treated with high-dose idarubicin”; Corsini, C., et al, British Journal of Cancer, 82(3), pp. 524-528 (2000).
“The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity”; Crouch, S.P.M., et al, Journal of Immunological Methods, 160, pp. 81-88 (1993).
“Experimental basis for increasing the therapeutic index of carboplatin in brain tumor therapy by pretreatment with WR compounds”; Dox, F., et al, Cancer Chemother Pharmacol, 28, pp. 308-310 (1991).
“Benzene-Induced Hematoxicity and Bone Marrow Compensation in B6C371 Mice”; Farris, Georgia M., et al, Fundamental and Applied Toxicology 36, pp. 119-129 (1997).
“Hematotoxicity on human bone barrow- and unbilical coard blood-derived progenitor cells and in vitro therapeutic index of methoxymorpholinyldoxorubicin and its metabolites”; Ghielmini, M., et al, Cancer Chemother Pharmacol 42, pp. 235-240 (1998).
“In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743)”; Ghielmini, M., et al, Annals of Oncology 9, pp. 989-993 (1998).
“Differential toxicity of anticancer drugs on late (GM-CFC) and early (LTC-IC) hemopoietic progenitors in vitro”; Ghielmini, M., et al, Cell Biology and Toxicology 15, pp. 395-404 (1999).
“Inhibition of CFU-E/BFU-E by 3′-Azido-3′-doexythymidine, Chlorpropamide, and Protoporphirin IX Zinc (II): A Comparisoon between Direct Exposure of Progenitor Cells and Long-Term Exposure of Bone Marrow Cultures”; Gribaldo, L., et al, Toxicological Sciences 58, pp. 96-101 (2000).
“Hemotopoietic dynamics in grey collies”; Haurie, Caroline, et al, Experimental Hematology 27, pp. 1139-1148 (1999).
“The Organization of Hemopoietic Tissue as Inferred from the Effects of 5-Fluorouracil”; Hodgson, G.S., Bradley, T.R. & Radley, J.M., Experimental Hematology, vol. 10, No. 1, pp. 26-35 (1982).
“In Vitro Production of CFU-S and Cells with Erythropoiesis Repopulating Ability by 5-Fluorouracil Treated Mouse Bone Marrow”; Hodgson, G.S., Bradley, T.R. & Radley, J.M., International Journal of Cell Cloning 1, pp. 49-56 (1983).
“Monoterpenes As Regulators Of Malignant Cell Proliferation”; Hohl, Raymond J., Adv. Exp. Med. Biol., vol. 401, pp. 136-146 (1996).
“The Myelotoxicity of chloramphenicol: in vitro and in vivo studies: I. In vitro effects on cells in culture”; Holt, D.E.,e t al, Hum. Exp. Toxicol., vol. 16, pp. 570-576 (1997).
“Colorimetric determination of inhibition of hematopoietic progenitor cells in solft agar”; Horowitz, D. & King, Andrew G., Journal of Immunological Methods 244, pp. 49-58 (2000).
“Erythroid Colony Formation in Cultures of Mouse and Human Bone Marrow: Analysis of the Requirement for Erythropoietin by Gel Filtration and Affinity Chromatography on Agarose-Concanavalin A”; Iscove, N., Sieber, F. & Winterhalter, H., Journal of Cell. Physiology, 83, pp. 309-320 (1974).
“A Miniaturized Agar Culture System for Cloning Human Erythropoietic Progenitor Cells”; Konwalinka, G., et al, Experimental Hematology, vol. 12, pp. 75-79 (1984).
“Use of the Microculture Kinetic Assay of Apoptosis to Determine Chemosensitivities of Leukemias”; Kravtsov, V.D., et al, Blood, vol. 92, No. 3, pp. 968-980 (1998).
“Chrono Biological Aspects Of Bone Marrow And Blood Cells”; Laerum, O.D. & Aardal, N.P., 11thInt'l Congress of Anatomy: Biological Rhythms in Structure and Function, pp. 87-97 (1981).
“Hematopoiesis occurs in rhythms”; Laerum, O.D., Experimental Hemotology 23, pp. 1145-1147 (1995).
“In Vitro Toxicity of A 3′-Azido-3′-Deoxythymidine and Hydroxyurea Combination on Normal Myeloid Progenitors”; Lerza, R., et al, Anticancer Research 18, pp. 2755-2758 (1998).
“Improved Plasma Culture System for Production of Erythrocytic Colonies In Vitro: Quantitative Assay Method for CFU-E”; McLeod, D.L., et al, Blood, vol. 44, No. 4, pp. 517-534 (1974
Becker Donna E.
Gabel Gailene Rio
HemoGenix, Inc.
Rosenbaum David G.
Rosenbaum & Associates, PC
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