Electrolysis: processes – compositions used therein – and methods – Electrolytic synthesis – Involving measuring – analyzing – or testing during synthesis
Patent
1996-10-03
1998-08-25
Bell, Bruce F.
Electrolysis: processes, compositions used therein, and methods
Electrolytic synthesis
Involving measuring, analyzing, or testing during synthesis
422 55, 422 56, 422 57, 422 59, 422 63, 422 82, 422119, 422129, 422138, 422188, 422196, 422197, 422232, 422233, 422236, 436 52, 436 55, 436 47, 436 48, 436 49, 436165, 436169, 206305, 2064595, C25B 1502
Patent
active
057980357
ABSTRACT:
A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of reaction conditions within the tubular member and of one or more reagents utilized in a reaction within the tubular members. A method of performing chemical synthesis on solid phase reactive material within a plurality of reaction vessels using a plurality of reaction stages resulting in final products and employing identifying indicia representing the reaction stages is also disclosed. The method includes reading the identifying indicia located on the reaction vessels, reacting one or more reagents within the reaction vessels under particular reaction conditions which may be determined by reading the identifying indicia, thereby synthesizing chemical compounds within the reaction vessels. The method allows chemical synthesis to occur according to a predetermined set of reactions and also allows for combinatorial chemistry to be performed utilizing random mix and split techniques. The final synthesized products may be tested for chemical or biological activity. The chemical structures of desired end products may be obtained by reading recorded information wherein the reaction conditions and reagents of reaction steps have been recorded, preferably in conjunction with the identifying indicia.
REFERENCES:
patent: 3531258 (1970-09-01), Merrifield et al.
patent: 3951741 (1976-04-01), Pfaender et al.
patent: 4252769 (1981-02-01), Hood et al.
patent: 4351762 (1982-09-01), Verlander et al.
patent: 4362699 (1982-12-01), Verlander et al.
patent: 4552922 (1985-11-01), Patchornik et al.
patent: 4631211 (1986-12-01), Houghten
patent: 4746490 (1988-05-01), Saneii
patent: 4800166 (1989-01-01), Horn et al.
patent: 4816513 (1989-03-01), Bridgham et al.
patent: 4861866 (1989-08-01), Durrum et al.
patent: 5102986 (1992-04-01), Coffey et al.
patent: 5169935 (1992-12-01), Hoeger et al.
patent: 5186898 (1993-02-01), Bridgham et al.
patent: 5188733 (1993-02-01), Wang et al.
patent: 5202418 (1993-04-01), Lebl et al.
patent: 5258454 (1993-11-01), Berg et al.
patent: 5286789 (1994-02-01), Okrongly et al.
patent: 5318679 (1994-06-01), Nishioka
patent: 5324483 (1994-06-01), Cody et al.
patent: 5338831 (1994-08-01), Lebl et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5387526 (1995-02-01), Garner et al.
patent: 5609826 (1997-03-01), Cargill et al.
patent: 5612002 (1997-03-01), Cody et al.
patent: 5663545 (1997-09-01), Marquiss
Chemical Abstracts, vol. 105, 1986; Abstract No. 97882m; vol. 104, 1986 Abstract No. 1 86857d. No Month Available.
Chemical Abstracts, vol. 88, 1978; Abstract No. 170484v. No Month Available.
Chemical Abstracts, vol. 76, 1972, Abstract No. 72776z.; vol. 77, 1972, Abstract No. 34910b. No Month Available.
Chemical abstracts, vol. 103, 1985, Abstract Nos. 178611h; 196394u. No Month Available.
Chemical Abstracts, vol. 83, 1975, AbstractNo. 43731v. No Month Available.
Chemical Abstracts, vol. 66, 1967, Abstract No. 18845b. No Month Available.
Chemical Abstracts, vol. 122, 1995, Abstract No. 10543f.; Abstract No. 10640k; Abstract No. 31956h No Month Available.
Chemical Abstracts, vol. 108, 1988, Abstract No. 222106b; Abstract No. 120766z. No Month Available.
Chemical Abstracts, vol. 117, 1992, Abstract No. 234542q. No Month Available.
Chemical Abstracts, vol. 118, 1993, Abstract No. 148037t.; Abstract No. 148052u. No Month Available.
Chemical Abstracts, vol. 119, 1993, Abstract No. 117846x. No Month Available.
Chemical Abstracts, vol. 121, 1994, Abstract No. 281191s. No Month Available.
Chemical Abstracts, vol. 106, 1987, Abstract No. 33451h; Abstract No. 52280t; Abstract No. 156848a No Month Available.
Chemical Abstracts, vol. 107, 1987, Abstract No. 7530j; vol. 109, 1988, Abstract Nos. 190792z; 190800a. No Month Available.
Chemical Abstracts, vol. 110, 1989, Abstract Nos. 58014p; 127789j; vol. 111, 1989, Abstract No. 58282v. No Month Available.
Chemical Abstracts, vol. 112, 1990, Abstract Nos. 99271e; 237306y. No Month Available.
Chemical Abstracts, vol. 113, 1990, Abstract Nos. 41334g; 115836w; vol. 97, 1982, Abstract No. 24208c. No Month Available.
Chemical Abstracts, vol. 114, 1991, Abstract Nos. 43554y; 62733x; 207784b. No Month Available.
Chemical Abstracts, vol. 115, 1991, Abstract Nos. 29887y; 67673h; 183890a; 183891b. No Month Available.
Chemical Abstracts vol. 101, 1984, Abstract No. 73078v; vol. 102, 1985 Abs. No. 149758k.
Grubbs Robert H.
Kirk Gregory L.
Bell Bruce F.
Pharmacopeia Inc.
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