Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis
Reexamination Certificate
2006-10-31
2006-10-31
Moran, Marjorie A. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Chemical analysis
C702S019000, C435S004000, C436S086000
Reexamination Certificate
active
07130747
ABSTRACT:
A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, producing a second sample slurry of a selected polycrystalline macromolecule material, one or more ligands and the solvent, obtaining a high resolution powder diffraction pattern on each of said first sample slurry and the second sample slurry, and, comparing the high resolution powder diffraction pattern of the first sample slurry and the high resolution powder diffraction pattern of the second sample slurry whereby a difference in the high resolution powder diffraction patterns of the first sample slurry and the second sample slurry provides a positive indication for the formation of a complex between the selected polycrystalline macromolecule material and at least one of the one or more ligands.
REFERENCES:
patent: 5434796 (1995-07-01), Weininger
patent: 5571902 (1996-11-01), Ravikumar et al.
patent: 6128582 (2000-10-01), Wilson et al.
patent: 6177280 (2001-01-01), Yan et al.
patent: 6229010 (2001-05-01), Crocker et al.
patent: 6230102 (2001-05-01), Tidor et al.
patent: 6297021 (2001-10-01), Nienaber et al.
patent: 6667299 (2003-12-01), Ahlem et al.
Heiney. “What is X-ray diffraction (XRD)”, 1996, on the world wide web at http://dept.physics.upenn.edu/˜heiney/talks/hires/whatis.html#SECTION00014000000000000000, 4 pages.
Yen-Ho Chu et al., “Affinity Capillary Electgrophoresis—Mass Spectrometry For Screening Combinatorial Libraries,” J. Chem. Soc., vol. 118, pp. 7827-7835, 1996.
Robert Karlsson et al., “Kinetic Analysis of Monoclonal Antibody-Antigen Interactions with a New Biosensor Based Analytical System,” Journal of Immunological Methods, vol. 145, pp. 229-240, 1991.
Shintaro Kumazawa et al., “Meed: A Program Package for Electron-Density-Distribution Calculation By the Maximum-Entropy Method,” J. Appl. Cryst., vol. 26, pp. 453-457, 1993.
G. A. Slim, “A Note On the Heavy-Atom Method,” Acta. Cryst., vol. 13, pp. 511-512, 1960.
Sidney Udenfriend et al., Scintillation Proximity Assay: A Sensitive and Continuous Isotopic Method for Monitoring Ligand/Receptor and Antigen/Antibody Interactions, Analytical Biochemistry, vol. 161, pp. 494-500, 1987.
R. B. Von Dreele, “Combined Rietveld and Stereochemical Restraint Refinement of a Protein Crystal Structure,” J. Appl. Cryst., vol. 32, pp. 1084-1089, 1999.
Rex A. Palmer, “X-Ray Crystallographic Studies of Protein-Ligand Interactions,” Chapter 1, pp. 1-98, 2001.
Romano T. Kroemer, “Molecular Modeling,” Chapter 2, pp. 99-121, 2001.
G. N. Ramachandran, Fourier Methods in Crystallography, pp. 1-33, John Wiley & Sons, Inc., New York, 1970.
Bryan John Smith, “Protein Sequencing Protocols,” pp. 17-24, Humana Press, Totowa, New Jersey, 1997.
Anthony w. Czarnik, “Accounts of Chemical Research,” Acc. Chem. Res., vol. 29, No. 2, pp. 112-113, 1996.
Linda C. Hsieh-Wilson et al., “Lessons From the Immune System: From Catalysis to Materials Science,” Acc. Chem. Res., vol. 29, No. 3, pp. 164-170, 1996.
Sheila Hobbs DeWitt et al., “Combinatorial Organic Synthesis Using Parke-Davis's Diversomer Method,” Acc. Chem, Res, vol. 29, No. 3, pp. 114-122, 1996.
Robert W. Armstrong et al., “Multiple-Component Condensation Strategies for Combinatorial Library Synthesis,” Acc. Chem. Res., vol. 29, No. 3, pp. 123-131, 1996.
Jonathan A. Ellman, “Design, Synthesis and Evaluation of Small-Molecule Libraries,” Acc. Chem. Res., vol. 29, No. 3, pp. 132-143, 1996.
E. M. Gordon et al., “Strategy and Tactics in Combinatorial Organic Synthesis, Applications to Drug Discovery,” Acc. Chem. Res., vol. 29, No. 3, pp. 144-154, 1996.
W. Clark Still, “Discovery of Sequence-Selective Peptide Binding by Synthetic Receptors Using Encoded Combinatorial Libraries,” Acc. Chem. Res., vol. 29, No. 3, pp. 155-163, 1996.
Hideo Toraya, “Positions-Constrained and Unconstrained Powder-Pattern-Decomposition Methods,” The Rietvels Method, Chapter 12, pp. 255-275, International Union of Crystallography, Oxford University Press, 1993.
R. B. Von Dreele, “Neutron Powder Diffraction,” Modern Powder Diffraction, Reviews in Mineralogy, vol. 20, Chapter 11, pp. 331-369, 1989.
John w. Erickson et al., “Macromolecular X-Ray Crystallography and NMR As Tools for Structure-Based Drug Design,” Annual Report in Medicinal Chemistry, vol. 27, pp. 271-289, 1992.
Martin R. Jefson, “Applications of NMR Spectroscopy to Protein Structure Determination,” Annual Reports in Medicinal Chemistry, vol. 23, pp. 275-283, 1988.
U. Jonsson et al., “Real-Time Biospecific Interaction Analysis Using Surface Plasmon Resonance and a Sensor Chip Technology,” Biotechniques, vol. 11, No. 5, pp. 620-627, 1991.
R. B. Von Dreele, “Protein-Drug Interaction,” Modern Drug Discovery, vol. 4, No. 5, pp. 83-84, May 2001.
Melinda Balbirnie et al., “An Amyloid-Forming Peptide From the Yeast Prion Sup35 Reveals a Dehydrate β-Sheet Structure for Amyloid,” Proc. Nat. Sci., vol. 98, No. 5, pp. 2375-2380, Feb. 27, 2001.
J. D. Bernal et al., “X-Ray and Crystallographic Studies of Plant Virus Preparations. III,” Journal of General Physiology, vol. 25, pp. 147-165, 1941.
W. F. van Gunsteren et al., “Biomolecular Simulation: The Gromos96 Manual and User Guide,” Biomos b.v., Zurich, Groningen, pp. 1-123, 1996.
Jan Drenth, “Principles of Protein X-Ray Crystallography,” Chapter 2, pp. 22-47, Springer Advanced Texts in Chemistry, 1999.
Allen C. Larson et al., “General Structrure Analysis System (GSAS),” Los Alamos National Laboratory Report, LAUR 86-748, pp. 1-224, 2001.
D'Amico Kevin
Von Dreele Robert B.
Cottrell Bruce H.
Los Alamos National Security LLC
Moran Marjorie A.
Smith Carolyn L.
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