High throughput screening method of drug for physiologically...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S023000, C435S032000

Reexamination Certificate

active

07435538

ABSTRACT:
The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use of a wheat embryo extract solution. The present inventors have strenuously studied to solve the matters above and finally completed the present invention by, in a system with the use of a wheat embryo, among cell-free protein synthesis means, constructing a synthesis system of a bioactive protein while sustaining its activities, and constructing a system for screening an inhibitor candidate to SARS 3CLpro, as an example using the synthesis system.

REFERENCES:
patent: 2002/0094523 (2002-07-01), Sakalian et al.
patent: 2003/0207290 (2003-11-01), Kenten et al.
patent: 2005/0042305 (2005-02-01), Endo et al.
patent: 2000-139468 (2000-05-01), None
patent: 2004-113186 (2004-04-01), None
patent: WO 03/064671 (2003-08-01), None
patent: WO 2003/064671 (2003-08-01), None
Schleif et al. “In vitro translation systems from higher organisms.” IN:Practical Methods in Molecular Biology, Springer-Verlag, New York. 1981. pp. 161-166.
Heinz et al (Antimicrobial Agents and Chemotherapy 40:276-270, 1996).
Anand et al (Science 300:1763-1767, Jun. 13, 2003, published online May 13, 2003).
English translation of International Preliminary Report on Patentability and Written Opinion of the International Searching Authority for PCT/JP2004/013071 mailed Jul. 5, 2006.
Heinz et al., “Simple In Vitro Translation Assay to Analyze Inhibitors of Rhinovirus Proteases,” Antimicrobial Agents and Chemotherapy, vol. 40, No. 1, Jan. 1996, pp. 267-270.
Anand et al., “Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs,” Science, vol. 300, Jun. 13, 2003, pp. 1763-1767.
Marra et al., “The Gemome Sequence of the SARS-Associated Coronavirus,” Science, vol. 300, May 30, 2003, pp. 1399-1404.
Copy of International Search Report for PCT/JP2004/013071 dated Dec. 7, 2004.
Copy of International Preliminary Report on Patentability for PCT/JP2004/013071 mailed Mar. 23, 2006.

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