Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1996-09-13
1998-11-10
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 911, 435 912, C12Q 170, C12Q 168, C12P 1934
Patent
active
058341811
ABSTRACT:
The present invention provides methods for identifying genetic alterations in a target sequence present in a nucleic acid sample, comprising immobilizing samples on a support, contacting the samples simultaneously with different purine and pyrimidine containing polymers under conditions of hybridization, separating the hybridized polymers from the samples; and identifying the hybridized polymers to identify the genetic alteration(s). The present invention also provides methods for identifying target sequences present in a nucleic acid sample, comprising immobilizing nucleic acid samples on a support, contacting the samples simultaneously different purine and pyrimidine containing polymers under hybridization conditions, separating the polymers from the complementary target sequence(s), and identifying the hybridized polymers to identify the target sequence(s). Further provided by the present invention are methods for identifying randomly permuted genetic alterations in a target sequence present in a nucleic acid sample, comprising immobilizing nucleic acid samples on a support, contacting the samples simultaneously with different purine and pyrimidine containing polymers under hybridization conditions, detecting hybridization between the polymers and the complementary target sequences, to identify the target sequence(s), separating the hybridized polymers from the complementary target sequences; and identifying randomly permuted genetic alterations present in the target sequence.
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Genzyme Corporation
Horlick Kenneth R.
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