Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2004-11-26
2009-10-20
Lam, Ann Y (Department: 1641)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
Reexamination Certificate
active
07604982
ABSTRACT:
The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.
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Notice of Preliminary Rejection for related Japanese patent application No. 2006-535278.
Chang Soo-Ik
Han Moon-Hi
Kang In-Cheol
Lee Yoon-Suk
Husch Blackwell Sanders Welsh & Katz
Lam Ann Y
Proteogen Inc.
Shekleton Gerald T.
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