High-throughput screening assays for modulators of nucleic acid

Details High-throughput screening assays for modulators of nucleic acid High-throughput screening assays for modulators of nucleic acid

1998-03-09

1999-12-07

Weber, Jon P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435233, G01N 3353, C12N 990

Patent

active

059981520

ABSTRACT:
This invention provides novel assays for topoisomerase activity and for identifying topoisomerase inhibitors. The assays include both solid-phase and liquid-phase methods that are amenable to high throughput screening methods. The assays of the invention are readily adaptable to numerous types of topoisomerase, and are capable of identifying novel classes of topoisomerase activity modulators.

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