High-throughput screening assay for inhibitors of nucleic acid h

Details High-throughput screening assay for inhibitors of nucleic acid h High-throughput screening assay for inhibitors of nucleic acid h

1996-03-14

1998-01-06

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

935 77, 935 78, 435196, C12Q 168

Patent

active

057053448

ABSTRACT:
The invention provides screening assays for identifying an inhibitor of a pathogenic helicase activity, e.g. a helicase derived from a pathogenic infectious organism such as a bacterium, protozoan or fungus. Helicase activity is detected by the solid-phase, preferential capture of retained (non-liberated) single-stranded nucleic acid comprising a detectable label.

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