High-throughput screening assay for cholesterol inhibitors...

Details High-throughput screening assay for cholesterol inhibitors... High-throughput screening assay for cholesterol inhibitors...

2006-05-23

2006-05-23

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving cholesterol

C435S004000

Reexamination Certificate

active

07049086

ABSTRACT:
The present invention provides a high-throughput screening assay to identify test agents as cholesterol inhibitors via mutant NCP1 mammalian cells. Also provided are cholesterol inhibiting agents identified in accordance with this assay and methods for using such agents to inhibit cholesterol accumulation in cells.

REFERENCES:
patent: 4939134 (1990-07-01), Javitt et al.
patent: 5091419 (1992-02-01), Ito et al.
patent: 5494791 (1996-02-01), Cohen
Millard et al., “Niemann-Pick Type C1 (NPC1) Overexpression Alters Cellular Cholesterol Homeostatis”, J. Biol. Chem. 2000 275 (49) :38445-38451.
Roff et al., “Type C Niemann-Pick Disease: Use of Hydrophobic Amines to Study Defective Cholesterol Transport”, Dev. Neurosci. 1991 13:315-319.

Affiliated with

Also associated with

Rating

High-throughput screening assay for cholesterol inhibitors... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High-throughput screening assay for cholesterol inhibitors..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High-throughput screening assay for cholesterol inhibitors... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3648214